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EC number: 454-800-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- pH4:
21.008 g citric acid monohydrat were dissolved in 200 ml sodium hydroxide solution (c = 1 mol/l). This solution were filled up to a volume of 1000 ml with distilled water. 44 ml of hydrochloric acid (c = 1 mol/l) was added to 560 ml of this solution and filled up to a volume of 1000 ml with distilled water. The solution was adjusted to pH 4,0 with sodium hydroxide or hydrochloric acid.
pH7:
13.61 g potassium dihydrogen phosphate were dissolved in 1000 ml distilled water. 29.63 ml of sodium hydroxide solution (c = 1 mol/l) were added to 500 ml of this solution and filled up to a volume of 1000 ml with distilled water. The solution was adjusted to pH 7.0 with sodium hydroxide or hydrochloric acid.
pH9:
7.46 g potassium chloride and 6.184 g boric acid were dissolved in 1000 ml distilled water. 500 ml of this solution were added to 21.30 ml sodium hydroxide (c = 1 mol/l) and filled up to a volume of 1000 ml with water. The solution was adjusted to pH 9.0 with sodium hydroxide or hydrochloric acid. - Details on test conditions:
- In a pretest it was determined that the decomposition at 50°C is below 50 % after 2.4 hours and higher than 10 % after 5 d for the pH 4, pH 7 and pH 9 values. According to the guideline the pretests at pH 4, pH 7 and pH 9 indicate that an examination of the hydrolysis kinetics is essential. Thus a full test was performed.
- Duration:
- 28.25 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 109.5 mg/L
- Duration:
- 24 h
- pH:
- 4
- Temp.:
- 55 °C
- Initial conc. measured:
- 110.2 mg/L
- Duration:
- 8 h
- pH:
- 4
- Temp.:
- 65 °C
- Initial conc. measured:
- 107.3 mg/L
- Duration:
- 32 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 104.7 mg/L
- Duration:
- 24 h
- pH:
- 7
- Temp.:
- 55 °C
- Initial conc. measured:
- 104.6 mg/L
- Duration:
- 8 h
- pH:
- 7
- Temp.:
- 65 °C
- Initial conc. measured:
- 108 mg/L
- Duration:
- 40 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 112.9 mg/L
- Duration:
- 24 h
- pH:
- 9
- Temp.:
- 55 °C
- Initial conc. measured:
- 105 mg/L
- Duration:
- 16 h
- pH:
- 9
- Temp.:
- 65 °C
- Initial conc. measured:
- 105.7 mg/L
- Preliminary study:
- In a pretest it was determined that the decomposition at 50°C is below 50 % after 2.4 hours and higher than 10 % after 5 d for the pH 4, pH 7 and pH 9 values. According to the guideline the pretests at pH 4, pH 7 and pH 9 indicate that an examination of the hydrolysis kinetics is essential. Thus a full test was performed.
- Transformation products:
- not specified
- pH:
- 4
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0.04 h-1
- DT50:
- 19.72 h
- pH:
- 4
- Temp.:
- 55 °C
- Hydrolysis rate constant:
- 0.06 h-1
- DT50:
- 11.53 h
- pH:
- 4
- Temp.:
- 65 °C
- Hydrolysis rate constant:
- 0.16 h-1
- DT50:
- 4.35 h
- pH:
- 7
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0.03 h-1
- DT50:
- 20.55 h
- pH:
- 7
- Temp.:
- 55 °C
- Hydrolysis rate constant:
- 0.06 h-1
- DT50:
- 11.71 h
- pH:
- 7
- Temp.:
- 65 °C
- Hydrolysis rate constant:
- 0.16 h-1
- DT50:
- 4.26 h
- pH:
- 9
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0.02 h-1
- DT50:
- 28.5 h
- pH:
- 9
- Temp.:
- 55 °C
- Hydrolysis rate constant:
- 0.04 h-1
- DT50:
- 15.62 h
- pH:
- 9
- Temp.:
- 65 °C
- Hydrolysis rate constant:
- 0.12 h-1
- DT50:
- 5.6 h
- Details on results:
- At pH 4 the half-life period was determined by extrapolating the results of the experiments at 50 °C, 55 °C and 65 °C to a temperature of 25°C. It was found to be 14.1 days.
At pH 7 the half-life period was determined by extrapolating the results of the experiments at 50 °C, 55 °C and 65 °C to a temperature of 25°C. It was found to be 16.4 days.
At pH 9 the half-life period was determined by extrapolating the results of the experiments at 50 °C, 55 °C and 65 °C to a temperature of 25°C. It was found to be 24.9 days. - Conclusions:
- The objective of this study was the determination of the abiotic degradation of the test item (the main compound), i.e. the determination of the hydrolysis rate as a function of the pH-value according to guideline 92/69/EEC, appendix, C.7 and OECD 111.
At pH 4 the half-life period was determined by extrapolating the results of the experiments at 50 °C, 55 °C and 65 °C to a temperature of 25°C. It was found to be 14.1 days.
At pH 7 the half-life period was determined by extrapolating the results of the experiments at 50 °C, 55 °C and 65 °C to a temperature of 25°C. It was found to be 16.4 days.
At pH 9 the half-life period was determined by extrapolating the results of the experiments at 50 °C, 55 °C and 65 °C to a temperature of 25°C. It was found to be 24.9 days. - Executive summary:
The objective of this study was the determination of the abiotic degradation of the test item (the main compound), i.e. the determination of the hydrolysis rate as a function of the pH-value according to guideline 92/69/EEC, appendix, C.7 and OECD 111.
At pH 4 the half-life period was determined by extrapolating the results of the experiments at 50 °C, 55 °C and 65 °C to a temperature of 25°C. It was found to be 14.1 days.
At pH 7 the half-life period was determined by extrapolating the results of the experiments at 50 °C, 55 °C and 65 °C to a temperature of 25°C. It was found to be 16.4 days.
At pH 9 the half-life period was determined by extrapolating the results of the experiments at 50 °C, 55 °C and 65 °C to a temperature of 25°C. It was found to be 24.9 days.
Reference
Description of key information
The objective of this study was the determination of the abiotic degradation of the test item (the main compound), i.e. the determination of the hydrolysis rate as a function of the pH-value according to guideline 92/69/EEC, appendix, C.7 and OECD 111.
At pH 4 the half-life period was determined by extrapolating the results of the experiments at 50 °C, 55 °C and 65 °C to a temperature of 25°C. It was found to be 14.1 days.
At pH 7 the half-life period was determined by extrapolating the results of the experiments at 50 °C, 55 °C and 65 °C to a temperature of 25°C. It was found to be 16.4 days.
At pH 9 the half-life period was determined by extrapolating the results of the experiments at 50 °C, 55 °C and 65 °C to a temperature of 25°C. It was found to be 24.9 days.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 16.4 d
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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