Piperazine, compound with phosphoric acid

Ecotoxicological Summary

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:

PNEC aqua (freshwater)

PNEC value:

0.21 mg/L

Assessment factor:

100

Extrapolation method:

assessment factor

PNEC freshwater (intermittent releases):

0.21 mg/L

Marine water

Hazard assessment conclusion:

PNEC aqua (marine water)

PNEC value:

0.021 mg/L

Assessment factor:

1 000

Extrapolation method:

assessment factor

STP

Hazard assessment conclusion:

PNEC STP

PNEC value:

146.723 mg/L

Assessment factor:

10

Extrapolation method:

assessment factor

Sediment (freshwater)

Hazard assessment conclusion:

PNEC sediment (freshwater)

PNEC value:

40.468 mg/kg sediment dw

Extrapolation method:

equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:

PNEC sediment (marine water)

PNEC value:

40.468 mg/kg sediment dw

Extrapolation method:

equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:

no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:

PNEC soil

PNEC value:

15.168 mg/kg soil dw

Extrapolation method:

equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:

no potential for bioaccumulation

Additional information

Classification is triggered based on available data, according to REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006.

Conclusion on classification

Classification of piperazine, compound with phosphoric acidfor effects in the environment

In determining the classification appropriate topiperazine, compound with phosphoric acid, it is necessary to consider all available evidence concerning its persistence, potential to accumulate and predicted or observed environmental fate and behaviour that may present a long-term and/or delayed danger to the structure and/or functioning of aquatic ecosystems. These points are considered below. 

 

Persistence

Data is available to demonstrate thatpiperazine, compound with phosphoric acidis not persistent in the aquatic environment. However, it is persistent in the sediment environment but with no diffusion (0%) in the sediment compartment by virtue of which its persistence in the sediment environment can be considered to be non-critical. It is not persistent in the soil compartment based upon its half life and hence it has been concluded thatpiperazine, compound with phosphoric acidis not persistent in nature.  

 

Thus,piperazine, compound with phosphoric acidis not classified as a persistent (P) chemical. 

 

Potential to accumulate

The log Kow values forpiperazine, compound with phosphoric acidis less than 4 (Log Kow = -0.5316). The potential forpiperazine, compound with phosphoric acidto bioaccumulate in the tissues of organisms that inhabit aquatic or terrestrial matrices is negligible as the BCF factor for the substance is less than 1000.  

 

The estimated BCF ofpiperazine, compound with phosphoric acidis highest 3.2 dimensionless and below the threshold of 2000. 

 

Thus,piperazine, compound with phosphoric aciddoes not satisfy the criterion for classification as bioaccumulative (B).

 

The toxicity values of fish, invertebrates and algae are LC50 = 1000 mg/L, EC50 = 21 mg/L and EC50 =479.618mg/L, respectively. The read across value of the parent chemical piperazine is suggesting classification in the Aquatic Chronic Category 3. Moreover, this chemical has a harmoinized classification in the Aquatic Chronic Category 3.

So,piperazine, compound with phosphoric acidsatisfies the environmental effects criterion for classification as toxic (T).

 

Thus it can be inferred thatpiperazine, compound with phosphoric acidis not a P B but toxic chemical.