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EC number: 241-793-5 | CAS number: 17832-28-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study is comparable to guideline with acceptable restrictions mostly due to reduced documentation and no GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-(vinyloxy)butan-1-ol
- EC Number:
- 241-793-5
- EC Name:
- 4-(vinyloxy)butan-1-ol
- Cas Number:
- 17832-28-9
- Molecular formula:
- C6H12O2
- IUPAC Name:
- 4-(ethenyloxy)butan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Vinyl-4-Hydroxybutylether
- Physical state: liquid
- Analytical purity: approximately 100%
- Expiration date of the lot/batch: April 1984
- Stability under test conditions: not reported
- Storage condition of test material:not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, 7950 Biberach
- Weight at study initiation: 179-218 g (male), 171-196 g (female)
- Fasting period before study: no food was given 16 h before application
- Housing: 5 per cage
- Diet: Kliba Laboratory diet 343 (Klingentalmuehle AG, Kaiseraugst, CH) ad libitum
- Water: tap water ad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12 (6:00-18:00 hrs/18:00-6.00hrs)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle (%): 21.50, 17.80, 14.70, 10.00, 4.64
- Amount of vehicle (if gavage): 10 ml/kg bw
- Justification for choice of vehicle: aqueous solution corresponds to physiological medium.
MAXIMUM DOSE VOLUME APPLIED: 2.18 ml for males and 1.96 ml for females - Doses:
- 2150, 1780, 1470, 1000 and 464 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical signs were observed many times on the day of application and daily after application. The animals were weighed before and on day 3, 4, 6, 7 and 13 after application.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology - Statistics:
- LD50 was calculated after Finney DJ Probit Analysis, Cambridge University Press, 3rd Ed, 1971.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 780 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 540 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 738 mg/kg bw
- Mortality:
- 2150 mg/kg bw: 5/5 females, 5/5 males within 1 day.
1780 mg/kg bw: 3/5 females, 2/5 males within 1 day.
1470 mg/kg bw: 1/5 female, 0/5 male within 1 day.
1000 mg/kg bw: 1/5 female, 0/5 male within 1 day.
464 mg/kg bw: no mortality was observed. - Clinical signs:
- other: 464 mg/kg bw: within 30 min after administration, dyspnoea, apathy, staggering gait, ruffled fur and poor general condition was observed. No signs were observed after 4 h. 1000 mg/kg bw and higher: within 15 min after administration, dyspnoea, apathy, abn
- Gross pathology:
- Congestion and hyperemia were observed in the heart of deceased animals. No changes were observed in sacrificed animals.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Executive summary:
This study is comparable to OECD 401 with acceptable restrictions mostly due to reduced documentation and no GLP. Groups of 5 rats per sex and dose group were administered with 2150, 1780, 1470, 1000 and 464 mg/kg bw of the test substance. The acute LD50 of the test substance in rats was found to be 1738 mg/kg bw for male and female animals. Within 30 min after administration, dyspnoea, apathy, staggering gait, ruffled fur and poor general condition was observed even in the lowest dose group. No signs were observed after 4 h. In the higher dose groups, dyspnoea, apathy, abnormal position, staggering gait, atony, loss of pain and corneal reflex, narcosis like condition, ruffled fur, cyanosis, dehydration and poor general condition was observed. No signs were observed 2 day after administration, except ruffled fur was noted in 1000 and 1470 mg/kg bw dose group till three and 6 day, respectively. Substance caused congestion and hyperemia in animals that died.
Conclusion: 4-(vinyloxy)butan-1 -ol is harmful after oral administration (GHS cat. 4)
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