Registration Dossier
Registration Dossier
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EC number: 205-355-7 | CAS number: 139-13-9
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- No information
- Author:
- Anonymous
- Year:
- 2 000
- Bibliographic source:
- IUCLID4 data set for triodiumnitrilotriacetate, 28 February 2000, page 137
Materials and methods
Test guideline
- Guideline:
- other: modified Draize method
- GLP compliance:
- no
- Type of study:
- Draize test
Test material
- Reference substance name:
- Nitrilotriacetic acid
- EC Number:
- 205-355-7
- EC Name:
- Nitrilotriacetic acid
- Cas Number:
- 139-13-9
- Molecular formula:
- C6H9NO6
- IUPAC Name:
- 2-[bis(carboxymethyl)amino]acetic acid
Constituent 1
In vivo test system
Test animals
- Species:
- human
Study design: in vivo (non-LLNA)
Induction
- Concentration / amount:
- 1% of an aqeous solution of a detergent containing 20% NTA
Challenge
- Concentration / amount:
- 1% of an aqeous solution of a detergent containing 20% NTA
- No. of animals per dose:
- 66
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 336
- Group:
- test chemical
- Dose level:
- 0.2%
- No. with + reactions:
- 0
- Total no. in group:
- 66
- Clinical observations:
- None. The reading was 2 weeks after a 9-fold induction (3 x per week)
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 336.0. Group: test group. Dose level: 0.2%. No with. + reactions: 0.0. Total no. in groups: 66.0. Clinical observations: None. The reading was 2 weeks after a 9-fold induction (3 x per week).
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
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