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EC number: 203-842-9 | CAS number: 111-18-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to fish.
Key value for chemical safety assessment
Additional information
A 96-h acute toxicity study was conducted with N,N,N',N'-Tetramethylhexamethylenediamine (TMHDA, CAS 111 -18 -2) in accordance with OECD guideline 203 and EEC Directive 92/69, Part C.1. to determine the ability of the test substance to produce toxic effects and determine the LC50 at all observation timepoints. The test was conducted with carp exposed to concentration ranging from 10 to 100 mg/L in a semi-static test system with daily renewal of the test solutions. The LC50 for carp exposed to TMHDA was 75 mg/L (nominal, analytically verified) with 0% mortality at 56 mg/L and 100% mortality at 100 mg/L (Tosoh Europe B.V., 1995, report no. 146385). These mortality results were observed after 24 hours of exposure. No additional mortality was recorded during the remaining testing period.
In addition, a GLP-guideline study by BASF AG (1987, report no. 10F0181/875068) was performed, testing the acute toxicity of N,N,N',N'-Tetramethylhexamethylenediamine towards Leuciscus idus. The concentrations were not analytically verified, but TMHDA is expected to be stable in water, due to the high water solubility (BASF SE 2013, report no. 11L00324), the moderate vapor pressure (VP = 0.124 hPa @20°C, Notox Project 2006, report no. 461407) and the low Henry's Law Constant (HLC = 7.57 E-03 Pa m³/mol @ 25°C, calculated with HENRYWIN v3.20, not in applicability domain, BASF SE 2016) of the substance.
No effect was observed in pH-adjusted test solution with a concentration of 100 mg/L. Thus, the mortality in the study mentioned above is considered to be caused by pH. Therefore, the LC50 is supposed to be higher than 100 mg/L at environmentally relevant pH values.
In conclusion, TMHDA is considered to be with high probability acutely not harmful to fish.
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