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Diss Factsheets
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EC number: 203-841-3 | CAS number: 111-17-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The data were derived from a secondary source (Cosmetic Ingredient Review (CIR) report) without access to original data. However, the data were peer-reviewed by an expert panel and the information presented is generally accepted as scientifically valid.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Final Safety Assessment of Thiodipropionic Acid and Its Dialkyl Esters as Used in Cosmetics
- Author:
- Diamante, C. et al.
- Year:
- 2 010
- Bibliographic source:
- Int J Toxicol 29(supp 3):137S-150S
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- A maximization test was performed on 26 subjects. 5 repeats of SLS and test material patches were applied to a site on the upper outer arm, volar forearm, or back of each subject under occlusive conditions.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,3'-thiodi(propionic acid)
- EC Number:
- 203-841-3
- EC Name:
- 3,3'-thiodi(propionic acid)
- Cas Number:
- 111-17-1
- Molecular formula:
- C6H10O4S
- IUPAC Name:
- 3-[(2-carboxyethyl)sulfanyl]propanoic acid
- Details on test material:
- - Name of test material (as cited in study report): Thiodipropionic acid (TDPA), 3,3’-thiodipropionic acid; bis(2-carboxyethyl) sulfide; ß,ß-thiodipropionic acid; 3,3’-thiobis(propanoic acid); 4-thiaheptanedioic acid; diethyl sulfide 2,2’-dicarboxylic acid; thiodihydracrylic acid
- Analytical purity: 2% in face cream formulation
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 26
- Sex: male (9) and female (17)
- Other: One subject did not complete the study for non-test article-related reasons (25 subjects therefore completed the study) - Controls:
- none
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test): maximization test
ADMINISTRATION
Induction Phase: During the induction phase, 0.5 mL of 0.25% SLS was applied to a site on the upper outer arm, volar forearm, or back of each subject under an occlusive patch for 24 h. Upon removal of the SLS patch, an occlusive patch containing 0.05 mL of the face cream containing 2% of Thiodipropionic acid (TDPA) was applied to the same site for 48 h (or 72 h on the weekends). The site was examined upon patch removal. If no irritation were present, the same SLS patch test patch sequence was repeated. This continued for a total of 5 induction exposures. If irritation developed at any point of the induction phase, the SLS patch was omitted.
Challange: After a 10-day nontreatment period, the challenge was performed in which a previously untreated site was pretreated with an occlusive patch of 0.5 mL of 5% SLS for 1 h followed by an occlusive 48 h patch containing 0.05 mL of the face cream containing 2% of Thiodipropionic acid (TDPA).
EXAMINATIONS
The challenge site was graded on a scale of 0 to 3 at 15 - 30 min and 24 h after patch removal.
Results and discussion
- Results of examinations:
- NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 0
- Number of subjects with negative reactions: 25
- Number of subjects with equivocal reactions: 0
- Number of subjects with irritating reactions: 0
OTHER RESULTS:
Of the remaining 25 subjects, no adverse or unexpected reactions were observed during the induction phase, and no evidence of sensitization was seen at challenge. The researchers concluded that a face cream containing 2% TDPA did “not possess a detectable contact-sensitizing potential.”
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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