Registration Dossier
Registration Dossier
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EC number: 237-307-6 | CAS number: 13734-41-3
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- other: QSAR
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Software used: DEREK Nexus, version 2.0.0, 2010 LHASA Ltd, Leeds, UK
- GLP compliance:
- no
Test material
- Reference substance name:
- N-[(tert-butoxy)carbonyl]-L-valine
- EC Number:
- 237-307-6
- EC Name:
- N-[(tert-butoxy)carbonyl]-L-valine
- Cas Number:
- 13734-41-3
- Molecular formula:
- C10H19NO4
- IUPAC Name:
- N-(tert-butoxycarbonyl)-L-valine
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Results and discussion
Results of examinations
- Details on results:
- A plausibile alert for hepatotoxicity of the N-[(tert-butoxy)carbonyl]-L-valine was detected by DEREK Nexus version 2.0.0.
Reason for plausible alert: Carbamate group
An equivocal alert for hepatotoxicity was detected.
Reason for equivocal alert: O-tertiary butyl carbamate group
Plausible: The weight of evidence supports the proposition.
Equivocal: There is an equal weight of evidence for and against the proposition.
Effect levels
open allclose all
- Dose descriptor:
- other: hepatoxicity alert for carbamate
- Basis for effect level:
- other: Plausibile alert
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified (migrated information)
- Dose descriptor:
- other: Rapid prototype: hepatotoxicity alert for o-tertiary butyl carbamate
- Basis for effect level:
- other: Equivocal alert
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified (migrated information)
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- A plausibile alert for hepatotoxicity of the N-[(tert-butoxy)carbonyl]-L-valine was detected by DEREK Nexus version 2.0.0.
Reason for plausible alert: Carbamate group
An equivocal alert for hepatotoxicity was detected.
Reason for equivocal alert: O-tertiary butyl carbamate group
Plausible: The weight of evidence supports the proposition.
Equivocal: There is an equal weight of evidence for and against the proposition.
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