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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Very old study. No Guideline.

Data source

Reference
Reference Type:
secondary source
Title:
BUA Stoffbericht 55: Chlortoluidine (3-Chlor-2-methylanilin, 5-Chlor-2-methylanilin, 3-Chlor-4-methylanilin)
Author:
BUA Beratergremium für umweltrelevante Altstoffe
Year:
1990
Bibliographic source:
Verlag Chemie Weinheim 1991

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A cat of 1890 g bw was treated 8 h / day over a period of 21 days with an air stream containing 0.25 mg/liter 3-chloro-2-methyltoluidin (nominal). In the flow off air stream the concentration was 0.004 mg/liter.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-chloro-o-toluidine
EC Number:
201-756-6
EC Name:
3-chloro-o-toluidine
Cas Number:
87-60-5
Molecular formula:
C7H8ClN
IUPAC Name:
3-chloro-2-methylaniline

Test animals

Species:
cat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
air
Analytical verification of doses or concentrations:
yes
Duration of treatment / exposure:
21 d
Frequency of treatment:
8 h / day
Doses / concentrations
Remarks:
Doses / Concentrations:
0.25 mg/l
Basis:
nominal conc.
No. of animals per sex per dose:
1

Results and discussion

Results of examinations

Clinical signs:
no effects observed
Mortality:
no mortality observed
Body weight and weight changes:
effects observed, treatment-related
Description (incidence and severity):
weight loss of 120 g
Food consumption and compound intake (if feeding study):
no effects observed
Food efficiency:
no effects observed
Water consumption and compound intake (if drinking water study):
no effects observed
Ophthalmological findings:
not specified
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
not specified
Histopathological findings: non-neoplastic:
not specified
Histopathological findings: neoplastic:
not specified
Details on results:
No symptoms observed. A weight loss of 120 g during the period was not considered to be caused by intoxication.

Effect levels

Dose descriptor:
conc. level:
Effect level:
0.25 mg/L air (nominal)
Based on:
test mat.
Sex:
not specified

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion