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Diss Factsheets
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EC number: 202-709-2 | CAS number: 98-87-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2.e: This study is sufficiently described and based on generally accepted scientific principles. GLP status is unknown. Therefore, this study should be considered as reliable with restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Structure-Activity Relationship of a Series of Sensory Irritants
- Author:
- Dudek B.R., Short R.D., Brown M.A. and Roloff M.V.
- Year:
- 1 992
- Bibliographic source:
- J. Toxicol. and Environm. Health., 37, 4, 511-518.
Materials and methods
- Principles of method if other than guideline:
- The authors estimated the potential sensory irritation of benzal chloride in Swiss-Webster mice exposed to a range of vapour concentrations during 10 min by following the decrease in their respiratory rate helped by a plethysmograph.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- respiratory irritation
Test material
- Reference substance name:
- α,α-dichlorotoluene
- EC Number:
- 202-709-2
- EC Name:
- α,α-dichlorotoluene
- Cas Number:
- 98-87-3
- Molecular formula:
- C7H6Cl2
- IUPAC Name:
- (dichloromethyl)benzene
- Reference substance name:
- Dichloromethylbenzene
- EC Number:
- 249-854-8
- EC Name:
- Dichloromethylbenzene
- Cas Number:
- 29797-40-8
- IUPAC Name:
- (dichloromethyl)benzene
- Details on test material:
- - Name of test material (as cited in study report): Alpha, Alpha-dichlorotoluene
- Analytical purity: 99% purchased from Aldrich chemical co.
No further data
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- Swiss Webster
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- Exposure period: 10 min
- Frequency of treatment:
- Once
- Post exposure period:
- None
- No. of animals per sex per dose:
- Four different concentrations unknown and four animal per dose
- Control animals:
- not specified
Results and discussion
- Details on results:
- The sensory irritation response measured was the average maximum percentage decrease in respiratory rate for four mice simultaneously exposed to vapor of the test chemical. The concentration that caused a 50 % decrease in the respiratory rate from baseline (RD 50) was calculated using least-squares regression analysis and gave a RD50 for benzal chloride of 27 ppm.
Applicant's summary and conclusion
- Conclusions:
- In the test conditions, the authors tested the sensory irritation potential of benzal chloride by following the decrease in the respiratory rate of mice exposed during ten minutes (RD50) to vapour of the substance. They estimated a RD50 around 27 ppm for benzal chloride.
However, at this level of information, no classification of specific target organ toxicity (here respiratory tract) could be done since the exposure period is only ten minutes. - Executive summary:
The authors tested the sensory irritation potential of benzal chloride by following the decrease in the respiratory rate of Swiss-Webster mice (weighing 23 -29 g) exposed during ten minutes (RD50) to vapours of the test substance. Respiratory frequency was monitored by a plethysmograph. The concentration that caused a 50 % decrease in the respiratory rate from baseline was calculated using least-squares regression analysis and gave a RD50 for benzal chloride of 27 ppm. This RD50 reflects the sensory irritation potential according to the authors.
No clear conclusion of the authors was drawn on the real sensory irritation potential of benzal chloride. However, this value may help for a weight of evidence for a classification as a specific target organ toxicant (here respiratory tract) following single exposure category 3.
This study is sufficiently described and is based on recognized scientific principles. Therefore, this study should be considered as reliable with restrictions and acceptable for assessment.
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