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EC number: 421-920-2 | CAS number: 154862-43-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity (oral): LD50 (male/female) >5000 mg/kg bw
Acute toxicity (inhalation): Waiver
Acute toxicity (dermal): LD50 (male/female) >2000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP Compliance, not OECD guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA-guideline 798.1175 (based on Directive 92/69/EEC,B.1)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- other: Rat, Sprague Dawley
- Vehicle:
- other: 0.5 % aqueous methylcellulose
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- Male: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 3150 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 5000 mg/kg bw; Number of animals: 5; Number of deaths:0
Female: 3150 mg/kg bw; Number of animals: 5; Number of deaths:0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: MORTALITY: All animals survived through the 14-day observation period. BODY WEIGHT: The body weight was within the normal range. ANIMAL OBSERVATION: Light colored feces were observed in all animals on day 1. Wi
- Gross pathology:
- Effects on organs:
No findings considered treatment related were noted at necropsy. - Interpretation of results:
- other: not classified
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Information from migrated NONS file, as per inquiry number 06-2120077351-60-0000, permission to refer granted by ECHA.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP Compliance, not OECD guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 92/69 EEC, B.3
- GLP compliance:
- yes
- Limit test:
- yes
- Species:
- other: Rat, WISTAR
- Type of coverage:
- semiocclusive
- Vehicle:
- other: Polyethylene glycol PEG 400
- Duration of exposure:
- 24h
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: There were no signs of systemic toxicity.
- Gross pathology:
- Effects on organs:
MACROSCOPIC FINDINGS: No macroscopic findings were noted. - Other findings:
- Signs of toxicity (local):
No local effects noted. - Interpretation of results:
- other: not classified
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Information from migrated NONS file, as per inquiry number 06-2120077351-60-0000, permission to refer granted by ECHA.
Additional information
Acute oral toxcity
There is one acute oral toxicity study in the rat available.
In an acute oral toxicity study (EPA-guideline 798.1175 (based on Directive 92/69/EEC,B.1)/GLP), Sprague Dawley rats (5/dose/sex) were administered 3,9-bis[2,4-bis(1-methyl-1-phenylethyl)phenoxy]-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5.5]undecane in 0.5 % aqueous methylcellulose by gavage at doses of 2000, 3150 and 5000 mg/kg bw and observed for 14 days. All animals survived through the 14-day observation period. The body weight was within the normal range. Light colored feces were observed in all animals on day 1. With the exception of one female rat exhibiting decreased feces on day 10 and 11, the animals appeared normal. No findings considered treatment related were noted at necropsy. The LD50 (male/female) was >5000 mg/kg bw.
Acute dermal toxcity
There is one acute dermal toxicity study in the rat available.
In an acute dermal toxicity study (Directive 92/69 EEC, B.3/GLP), Wistar rats (5/dose/sex) were dermally exposed (semi-occlusive) to
3,9-bis[2,4-bis(1-methyl-1-phenylethyl)phenoxy]-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5.5]undecane wetted in Polyethylene glycol PEG 400 at doses of 2000 mg/kg bw for 24 hours. There were no deaths as a result of treatment with the test article. The body weight gain of the animal was within the normal range of this strain and age. There were no signs of systemic toxicity and no local effects noted.. No macroscopic findings were noted. The LD50 (male/female) was >2000 mg/kg bw.
Both studies are suitable to use in the human health risk assessment.
Justification for classification or non-classification
Based on the available information in the dossier, the substance 3,9-bis[2,4-bis(1-methyl-1-phenylethyl)phenoxy]-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5.5]undecane (CAS No. 154862-43-8) does not need to be classified for acute toxicity or specific target organ toxicity - single exposurewhen the criteria outlined in Annex I of 1272/2008/EC are applied.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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