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EC number: 265-088-7 | CAS number: 64741-86-2 A complex combination of hydrocarbons obtained by subjecting a petroleum distillate to a sweetening process to convert mercaptans or to remove acidic impurities. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 150°C to 345°C (302°F to 653°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- This report is of limited use because the white oil was used as a control and the responses to it were not compared to an untreated control. Nevertheless it provides supportive information of the lack of effects in a gavage study of 13 week duration.
Data source
Reference
- Reference Type:
- publication
- Title:
- Assessment of the potential reproductive and subchronic toxicity of EDS coal liquids in Sprague-Dawley rats
- Author:
- McKee, R.H., Plutnick, R.T., Traul, K.A.
- Year:
- 1 987
- Bibliographic source:
- Toxicology 46:267-280
Materials and methods
- Principles of method if other than guideline:
- No guideline was explicitly stated, but the protocol appears to follow OECD Guideline 408 (Repeated Dose 90-day Oral Toxicity in Rodents) with deviations. The white oil was used as a control and the responses to it were not compared to an untreated control.
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Acid-treated white oil
- IUPAC Name:
- Acid-treated white oil
- Details on test material:
- IUCLID4 Test substance: other TS: White oil
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Only the information on controls will be summarized here since the experimental samples were not white oils, and therefore, not relevant to this summary. The control group comprised 90 females and 36 males and the white oil was administered orally by gavage at a dose of 5 ml/kg five times weekly for 13 weeks.
- Duration of treatment / exposure:
- 90 days
- Frequency of treatment:
- 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5 ml/kg/day
Basis:
- No. of animals per sex per dose:
- 90 females, 36 males
- Control animals:
- no
Examinations
- Observations and examinations performed and frequency:
- At the end of 13 weeks dosing 18 females were removed from the study for an evaluation of repeat dose toxicity. The males were then used for mating and after mating were evaluated for repeat dose toxicity. Fourteen days after cessation of administration of white oil, blood samples were collected; the animals were sacrificed and necropsied. A wide range of haematological and clinical chemical measurements were made, major organs were weighed and a wide range of tissues were examined histologically.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- not specified
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- >= 5 other: mL/kg bw/day
- Sex:
- male/female
- Basis for effect level:
- other: lack of effects
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Although effects were noted in those groups of animals exposed to the test materials, the report made no comment that the control values (i.e. those for white oil exposed animals) were outside of the normal range for control animals. Furthermore no adverse histological observations were made for those animals exposed to the white oil.
Applicant's summary and conclusion
- Conclusions:
- This report is of limited use because the white oil was used as a control and the responses to it were not compared to an untreated control. Nevertheless it provides supportive information of the lack of effects in a gavage study of 13 week duration. No effects were seen in male or female rats dosed with white oil at 5 mL/kg bw/day for 90 days. The NOAEL is therefore >= 5 mL/kg bw/day.
- Executive summary:
White oil was used as vehicle and also as control substance in a combined 90 -day repeat dose and reproductive toxicity study of EDS coal liquids. Only the information on controls will be summarized here since the experimental samples were not white oils, and therefore, not relevant to this summary.
The control group comprised 90 females and 36 males and the white oil was administered orally by gavage at a dose of 5 ml/kg five times weekly for 13 weeks. At the end of 13 weeks dosing 18 females were removed from the study for an evaluation of repeat dose toxicity. The males were then used for mating and after mating were evaluated for repeat dose toxicity. Fourteen days after cessation of administration of white oil, blood samples were collected; the animals were sacrificed and necropsied. A wide range of haematological and clinical chemical measurements were made, major organs were weighed and a wide range of tissues were examined histologically.
Although effects were noted in those groups of animals exposed to the test materials, the report made no comment that the control values (i.e. those for white oil exposed animals) were outside of the normal range for control animals. Furthermore no adverse histological observations were made for those animals exposed to the white oil.
This study was given a Klimisch score of 4 and classified as not assignable because this report is of limited use. The white oil was used as a control and the responses to it were not compared to an untreated control. Nevertheless it provides supportive information of the lack of effects in a gavage study of 13 week duration.
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