Registration Dossier
Registration Dossier
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EC number: 412-720-6 | CAS number: 156653-67-7
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 May 1993 to 07 May 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to EU and OECD test guideline in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- other: Estimation as HPLC method deemed to be redundant.
- Partition coefficient type:
- octanol-water
Test material
- Details on test material:
- See below
Constituent 1
Study design
- Analytical method:
- photometric method
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- -6
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not referenced in study report
- Details on results:
- The application of the HPLC method is not possible since the measurement of log of the test substance can not be performed in its non-ionised form. Regarding the estimation result even chromatography at very low pH values does not make sense. Based on investigations of similar test substances one can predict that the main components would elute in the range of the dead volume, i.e. log Pow < 0.
Due to the poor solubility of the test substance in n-octanol compared to the solubility in water and the log Pow estimated to be in range of -6 the application of the flask-shaking method is senseless either.
Applicant's summary and conclusion
- Conclusions:
- Final result: log Pow = -6
- Executive summary:
Study conducted to EU test guidance 84/449/EEC, V, A.8. and OECD test guideline 117 in compliance with GLP.
The application of the HPLC method is not possible since the measurement of log of the test substance can not be performed in its non-ionised form. Regarding the estimation result even chromatography at very low pH values does not make sense. Based on investigations of similar test substances one can predict that the main components) would elute in the range of the dead volume, i.e. log Pow< 0.
Due to the poor solubility of the test substance in n-octanol compared to the solubility in water and the log Powestimated to be in range of -6 the application of the flask-shaking method is senseless either.
Final result :
log Pow= -6
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