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EC number: 700-534-0 | CAS number: 117172-56-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-05-14 to 2009-05-15
- Reliability:
- 1 (reliable without restriction)
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guidelines for the Testing of Chemicals Part 431, adopted 13. Apr. 2004, In vitro Skin Corrosion: Human Skin Model Test
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.40 (In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER))
- Deviations:
- no
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3,3,12,12-tetramethoxy-2,13-dioxa-7,8-dithia-3,12-disilatetradecane; 5-(7,7-dimethoxy-2-oxo-8-oxa-3-thia-1-aza-7-silanonan-1-yl)-1-[(7,7-dimethoxy-2-oxo-8-oxa-3-thia-1-aza-7-silanonan-1-yl)methyl]-1,3,3-trimethylcyclohexane; [3-({[(3-isocyanato-3,5,5-trimethylcyclohexyl)methyl]carbamoyl}sulfanyl)propyl]trimethoxysilane; [3-({[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]carbamoyl}sulfanyl)propyl]trimethoxysilane
- EC Number:
- 700-534-0
- Cas Number:
- 117172-56-2
- Molecular formula:
- Not applicable: UVCB substance, see section 1.2 and 1.4. The UVCB substance consits of differnt products consiting of differnt isomers: Product I and Product II cannot analytically be distinguished and moreover, Product I-III are expected to consist of isomers that can neither analytically be identified nor quantified.
- IUPAC Name:
- 3,3,12,12-tetramethoxy-2,13-dioxa-7,8-dithia-3,12-disilatetradecane; 5-(7,7-dimethoxy-2-oxo-8-oxa-3-thia-1-aza-7-silanonan-1-yl)-1-[(7,7-dimethoxy-2-oxo-8-oxa-3-thia-1-aza-7-silanonan-1-yl)methyl]-1,3,3-trimethylcyclohexane; [3-({[(3-isocyanato-3,5,5-trimethylcyclohexyl)methyl]carbamoyl}sulfanyl)propyl]trimethoxysilane; [3-({[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]carbamoyl}sulfanyl)propyl]trimethoxysilane
- Reference substance name:
- Reaction products of 3- (trimethoxysilyl)propane-1-thiol and 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane (1:1)
- IUPAC Name:
- Reaction products of 3- (trimethoxysilyl)propane-1-thiol and 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane (1:1)
- Details on test material:
- - Name of test material: Intermediate 36
- Colour: light yellow
- Physical state: liquid
- Purity: >99%
Constituent 1
Constituent 2
Test animals
- Species:
- human
Test system
- Type of coverage:
- open
- Preparation of test site:
- other: EpiDerm Skin Model (EPI-200)
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: not applicable
- Duration of treatment / exposure:
- 3 minutes and one hour
- Observation period:
- not applicable
- Number of animals:
- not applicable
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: cell viability
- Basis:
- mean
- Time point:
- other: 3 minutes
- Remarks on result:
- other: 83.6 % referring to negative control
- Irritation parameter:
- other: cell viability
- Basis:
- mean
- Time point:
- other: 1 hour
- Remarks on result:
- other: 92.8 % referring to negative control
- Other effects:
- not applicable
Any other information on results incl. tables
Irritant / Corrosive response data:
The value of the positive control induced a decrease in the relative absorbance as com-pared to the negative control to 24.5% for the three minutes treatment interval and 14.9% for the one hour treatment interval thus ensuring the validity of the test system. For these reasons, the result of the test is considered valid.
The values of the negative control were well above the required acceptability criterion of mean OD > 0.8 for both treatment interval thus showing the quality of the tissues.
After three minutes treatment, the relative absorbance values were decreased to 83.6%. This value is well above the threshold for corrosivity (50%). After one hour treatment rela-tive absorbance values were reduced to 92.8%. This value is well above the threshold for corrosivity (15%). Thus, the test item is considered as not corrosive.
Applicant's summary and conclusion
- Interpretation of results:
- other: not corrosive / irritant
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Due to the absence of corrosive effects in this in vitro study, Intermediate 36 is considered not corrosive. In general, this in vitro study type does neither provide adequate information on skin irritation, nor allow the subcategorisation of corrosive substances as permitted in the Globally Harmonised Classification System (GHS). Because of the lack of irritating potential in the actual study, an in vivo study on skin irritation according to EU method B.4 resp. OECD 404 was performed additionally.
- Executive summary:
The study procedure employed a human skin model and was based on the following guidelines - Organisation for Economic Co-operation and Development (OECD), OECD Guidelines for Testing of Chemicals, Draft Proposal for a new guideline no. 431: In Vitro Skin Corrosion: Human Skin Model Test (Draft 20 February 2004). - European Economic Community (EEC). Adapting to technical progress for the twenty-sixth time Annex V of the EEC Directive 67/548/EEC, Part B: Methods for the Determination of Toxicity; B.40: "Skin corrosion". EEC Publication Commission Directive (08-06-2000). The study evaluates the corrosive properties of test substance on a human three dimensional epidermal model (EpiDerm (EPI- 200)). The possible corrosive potential of the test substance was tested through topical application for 3 minutes and 1 hour exposure. 50 µL of Intermediate 36 was applied unchanged (undiluted) directly on top of the skin tissue. The test substance was dissolved in the H2O demin and spread over the tissue. The positive control (Potassium hydroxide, 8.0 mol/L) induced a decrease in the relative absorbance as compared to the negative control to 24.5% for the three minutes treatment interval and 14.9% for the one hour treatment interval thus ensuring the validity of the test system. For these reasons, the result of the test is considered valid. The values of the negative control were well above the required acceptability criterion of mean OD > 0.8 for both treatment interval thus showing the quality of the tissues. Skin corrosion is expressed as the remaining cell viability after exposure to the test substance. The relative mean tissue viability obtained after 3 minutes and 1 hour treatment with the test substance compared to the negative control tissues was 83.6 % and 92.8 %, respectively. Since the mean relative tissue viability for the test substance was not below 50 % after 3 minutes treatment and not below 15 % after 1 hour treatment the test substance is considered to be not corrosive.
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