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EC number: 220-836-1 | CAS number: 2915-57-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 November 2012 to 19 December 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Water solubility:
- < 0 g/L
- Temp.:
- 20.8 °C
- pH:
- 7
- Remarks on result:
- other: Temperature ranged from 20.7 to 20.9 °C
- Details on results:
- Initially, seven to nine of the fractions were collected from the test system for each of the respective flow rates for the evaluation of the water solubility. The mean water solubility of bis(2-ethylhexyl) succinate was determined to be 0.00000182 ± 0.00000042 g/L at a flow rate of 25 mL/hour and 0.00000048 ± 0.00000022 g/L at a flow rate of 12.5 mL/hour using the column elution method. Due to the large difference (%D = 125 %) between these two readings (guideline criteria is 30 %), additional sample fractions were collected at both 12.5 and 25 mL/hr flow rates using several different columns. Measured concentrations were highly variable ranging from 0.00000017 to 0.0000034 g/L.
Turbidity values for all fractions ranged from 0.20 to 2.02 NTU for the samples analyzed. On each sampling occasion, the results of the turbidity measurements were also variable and exceeded the concurrent blank buffer measurements. To confirm that the turbidity was from the test material and not the column itself, turbidity measurements were taken using buffer and columns that contained glass beads but no test material. These turbidity readings including the column were higher than the buffer reading, but lower than a larger majority of the sample readings. There was no correlation between flow rate and the turbidity. There was also no apparent correlation between sample concentration and turbidity.
These results indicated that there was undissolved material present in the samples. It is likely that the undissolved material observed in the samples is attributed to break-through of the test material from the column due to the test material being a liquid. The highest measured concentration during this testing was 0.0000034 µg/L and therefore it can conservatively be estimated that the water solubility for this bis(2-ethylhexyl) succinate is < 0.00000500 g/L. - Conclusions:
- Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
Under the conditions of the study the water solubility of the test material was stipulated to be less than 0.00000500 g/L. - Executive summary:
The water solubility of the test material was determined in a GLP study which was conducted in accordance with the standardised guideline OECD 105. Undissolved test material was observed during preliminary testing via the flask method and so definitive testing was performed via the column elution method. Testing was performed at pH 7. Under the conditions of the study, the water solubility of the test material in pH 7 buffer was determined to be 0.00000182 and 0.00000048 g/L at flow rates of approximately 25 and 12 mL/hour, respectively. Turbidity values for all fractions ranged from 0.20 to 2.02 NTU for the samples analysed. These results indicated that there was undissolved material present in the samples. The presence of the undissolved material observed in the samples was attributed to break-through of the test material from the column due to the test material being a liquid. Due to the inconsistency of the concentration results for the 25 and 12 mL/hr flow rates and the likely release of undissolved test material from the support matrix, as indicated by the turbidity results, the water solubility result for this study was reported as less than 0.00000500 g/L.
Reference
Table 1: Results for the determination of water solubility for Bis(2‑ethylhexyl) Succinate in pH 7 buffer
Replicate |
Measured Water Solubility (g/L) |
|||
Column Flow Rate |
||||
25 mL/hour |
pHa |
12 mL/hour |
pHa |
|
pH 7 Buffer |
||||
1 |
0.00000343 |
7 |
<0.000000294 |
7 |
2 |
0.00000166 |
7 |
0.00000044 |
7 |
3 |
0.00000142 |
7 |
0.00000051 |
7 |
4 |
0.00000141 |
7 |
0.00000044 |
7 |
5 |
0.00000163 |
7 |
0.00000137 |
7 |
6 |
0.00000189 |
7 |
0.00000107 |
7 |
7 |
0.00000216 |
7 |
0.00000052 |
7 |
8 |
0.00000256 |
7 |
||
9 |
0.00000333 |
7 |
||
Mean: |
0.00000182 |
0.00000073 |
||
Standard Deviation: |
0.000000042 |
0.0000004 |
||
% Relative Standard Deviation: |
23.00% |
54.50% |
||
Overall Mean: |
0.00000132 |
|||
Overall Standard Deviation: |
0.00000075 |
|||
Overall % Relative Standard Deviation: |
57.10% |
a pH measurements were recorded with EMD pH strips.
Description of key information
Experimental study conducted according to recognised testing guideline with GLP certification.
Key value for chemical safety assessment
- Water solubility:
- 0 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material was determined in a GLP study which was conducted in accordance with the standardised guideline OECD 105. Undissolved test material was observed during preliminary testing via the flask method and so definitive testing was performed via the column elution method. Testing was performed at pH 7. Under the conditions of the study, the water solubility of the test material in pH 7 buffer was determined to be 0.00000182 and 0.00000048 g/L at flow rates of approximately 25 and 12 mL/hour, respectively. Turbidity values for all fractions ranged from 0.20 to 2.02 NTU for the samples analysed. These results indicated that there was undissolved material present in the samples. The presence of the undissolved material observed in the samples was attributed to break-through of the test material from the column due to the test material being a liquid. Due to the inconsistency of the concentration results for the 25 and 12 mL/hr flow rates and the likely release of undissolved test material from the support matrix, as indicated by the turbidity results, the water solubility result for this study was reported as less than 0.00000500 g/L.
The study was performed in line with GLP and an accepted standardised guideline with a high level of reporting. The study was assigned a reliability score of 1 and considered suitable for assessment as an accurate reflection of the substance.
The available data are considered to be complete and the result determined, water solubility < 0.00000500 g/L at 20.7 - 20.9 °C (pH 7), was taken forward for risk assessment.
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