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EC number: 404-360-3 | CAS number: 119313-12-1 CG 25-369; IRGACURE 369; TK 11-319
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD-GUIDELINE No. 301 B) (Paris 1981)
- Deviations:
- yes
- Remarks:
- The volume of the test solution was reduced from 3.0 L to 1.5 L.
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Sewage treatment plant of CH - 4153 Reinach, Switzerland
- Pretreatment: According to guideline - Duration of test (contact time):
- 28 d
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: According to guideline
- Solubilising agent (type and concentration if used): The test substance was added to the medium, homogenized with Nonylphenol 10E05P0
- Test temperature: 22± 2 °C
- pH adjusted: No
- Aeration of dilution water: Yes, 24 hours in the test vessel
TEST SYSTEM
- Culturing apparatus: 2 Liter flasks equipped with gas inlet and magnetic stirrer
- Number of culture flasks/concentration:
- Method used to create aerobic conditions: Air flow, appr. 25 mL/min free of carbon dioxide
- Method used to create anaerobic conditions:
- Details of trap for CO2 and volatile organics if used: Absorbers filled with 200 mL 0.05 N sodium hydroxide
SAMPLING
- Sampling frequency: At day 4, 7, 11, 15, 18, 22, 27, and 28
- Sampling method: Determination of the initial CO2 of the 0.05 N sodium hydroxide and the CO2 absorbed in the absorbers
CONTROL AND BLANK SYSTEM
- Inoculum blank: Yes
- Other: Vehicle control - Reference substance:
- aniline
- Remarks:
- 20 mg/L
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 28 d
- Remarks on result:
- other: 10 mg test substance/L
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 3
- Sampling time:
- 28 d
- Remarks on result:
- other: 20 mg test substance/L
- Results with reference substance:
- Biodegradation 87.2 % in 28 days
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- After 28 days, the substance achieved 3% biodegradation - thus EC 404-363-3 is not readily biodegradable according to OECD criteria.
- Executive summary:
In this guideline (OECD 301 B) study conducted with GLP certification, the test material (EC 404-363-3) was determined to not be readily biodegradable. The test was conducted in aerobic conditions, using an adapted sludge sourced from a municipal sewerage treatment plant. 3% test material biodegradation was observed 28 days (CO2 evolution).
Reference
Table 1. CO2 evolution in the controls and in the reference substance cultures
Day |
CO2 evol. | CO2 evol. | Biodegrad. | |||||
Blank | Blank + Vehicle | Aniline (20 mg/L) | ||||||
(mg) | (mg)* | (mg) | (mg)* | (mg) | (mg)* | (%) | (%)* | |
4 | 6 | 6 | 7 | 7 | 38.5 | 38.5 | 45.3 | 45.3 |
7 | 3 | 9.1 | 4 | 11 | 20.7 | 59.2 | 24.3 | 69.6 |
11 | 3.9 | 12.9 | 3.6 | 14.6 | 7.4 | 66.6 | 8.7 | 78.3 |
15 | 3.8 | 16.8 | 4.4 | 18.9 | 2.4 | 69 | 2.8 | 81.1 |
18 | 2.8 | 19.6 | 3.1 | 22 | 4.4 | 73.4 | 5.2 | 86.3 |
22 | 3.3 | 22.9 | 3.9 | 25.9 | -1.2 | 72.2 | -1.4 | 84.9 |
27 | 6.9 | 29.8 | 5.9 | 31.9 | -0.5 | 71.7 | -0.6 | 84.3 |
28 | -0.8 | 29 | -0.1 | 31.7 | 2.5 | 74.2 | 2.9 | 87.2 |
* cumulative values
For calculation of the degradation, the Blank+Vehicle is used. The Blank shows the behavior of the inoculum.
Table 2. CO2 evolution in TK 11319 cultures
Day | Concentration 10 mg/L | Concentration 20 mg/L | ||||||
CO2 evol. | Biodegrad. | CO2 evol. | Biodegrad. | |||||
(mg) | (mg)* | (%) | (%)* | (mg) | (mg)* | (%) | (%)* | |
4 | 0.2 | 0.2 | 0.4 | 0 | 2.5 | 2.5 | 3 | 3 |
7 | -1 | -0.8 | -2.4 | -2 | -1.2 | 1.2 | -1.5 | 2 |
11 | -0.1 | -1 | -0.4 | -2 | 0.4 | 1.7 | 0.5 | 2 |
15 | -0.6 | -1.6 | -1.5 | -4 | -0.4 | 1.3 | -0.5 | 2 |
18 | 0.5 | -1.1 | 1.2 | -3 | 0.6 | 1.9 | 0.7 | 2 |
22 | -1.6 | -2.6 | -3.8 | -6 | -1.3 | 0.6 | -1.5 | 1 |
27 | -0.1 | -2.8 | -0.4 | -7 | 0.7 | 1.2 | 0.8 | 2 |
28 | 1.8 | -1 | 4.4 | -2 | 1.4 | 2.6 | 1.7 | 3 |
* cumulative values
The negative degradation values are within the variation of the method.
Description of key information
Study carried out according to guideline and with GLP compliance.
Key value for chemical safety assessment
Additional information
A test on ready biodegradability was conducted according to GLP and OECD 301B (CIBA-GEIGY Ltd. 1989). After 28 d only 3% biodegradation was observed. Therefore, the test substance is poorly biodegradable and not readily biodegradable (according to OECD criteria).
The test substance is not readily biodegradable (according OECD criteria). Poorly biodegradable.
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