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EC number: 240-827-6 | CAS number: 16774-21-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 6 November 2012 and 6 December 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.1 bis (Acute Oral Toxicity - Fixed Dose Procedure)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Diammonium hexanitratocerate
- EC Number:
- 240-827-6
- EC Name:
- Diammonium hexanitratocerate
- Cas Number:
- 16774-21-3
- Molecular formula:
- CeN6O18.2H4N
- IUPAC Name:
- diammonium cerium(IV) nitrate
- Test material form:
- solid: crystalline
- Details on test material:
- - Name as mentioned in the study report: cerium ammonium nitrate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories UK Ltd., Oxon, UK
- Age at study initiation: 12 weeks
- Weight at study initiation: female at 2000 mg/kg: 153 g at day 0; range for females at 300 mg/kg: 152 to 160 g
- Fasting period before study: Animals had free access to food and drinking water except for overnight immediately prior to dosing
- Housing: Animals were housed in suspended solid-floor polypropylene cages furnished with wood flakes in groups of up to four animals.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-25 °C
- Humidity (%): between 30 and 70%
- Air changes (per hr): at least 15 changes per hour.
- Photoperiod (hrs dark / hrs light): 12 hours light / 12 hours darkness
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- distilled water
- Details on oral exposure:
- The test item formulations were not adjusted for the purity of the test item. For the purpose of the study the test item was freshly prepared, as required, as a solution in distilled water.
The test item was formulated within two hours of being applied to the test system. It is assumed that the formulation was stable for this duration. - Doses:
- Sighting test: 2000 mg/kg and 300 mg/kg
Main test: 300 mg/kg - No. of animals per sex per dose:
- one female at 2000 mg/kg
five females at 300 mg/kg - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations were made 30min, 1, 2, and 4 hours after dosing and then daily for up to 14 days. Morbidity and mortality checks were made twice daily. Individual bodyweights were recorded on day 0 (the day of dosing) and on days 7 and 14 or at death.
- Necropsy of survivors performed: yes: at the end of the observation period the surviving animals were killed by cervical dislocation. All animals were subjected to gross necropsy. This consisted of an external examination and opening of the abdominal and thoracic cavities. The appearance of any macroscopic abnormalities was recorded. No tissues were retained. - Statistics:
- No data
Results and discussion
- Preliminary study:
- The animal treated at a dose level of 2000 mg/kg was found dead one day after dosing. Signs of systemic toxicity noted in the animal treated at a dose level of 2000 mg/kg on the day of dosing were hunched posture, pilo-erection and ptosis. Haemorrhage and epithelial sloughing of the gastric mucosa was noted at necropsy. No deaths or signs of systemic toxicity were observed at a dose level of 300 mg/kg.
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 300 - 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no deaths at a dose level of 300 mg/kg.
- Clinical signs:
- other: There were no signs of systemic toxicity at a dose level of 300 mg/kg.
- Gross pathology:
- Raised limiting ridge of the stomach was noted at necropsy of one animal treated at a dose level of 300 mg/kg. No abnormalities were noted at necropsy of four animals.
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral LD50 was estimated to be in the range of 300 - 2000 mg/kg bw. The test substance is therefore considered classified as category 4 acute oral toxicant according to CLP Regulation.
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