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Diss Factsheets
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EC number: 221-259-8 | CAS number: 3048-64-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The read across substance ENB has been tested for aquatic toxicity in three trophic levels including fish, daphnia and algae. For acute toxicity, a 96hEC50 of 3.68 mg/L for algae (OECD TG 201, Selenastrum capricornutum by biomass), a 48hEC50 values of 7.3 mg/L for daphnid (OECD TG 202, Daphnia magna, immobilization), and for fish a 96hLC50 of 7.6 mg/L (Brachydanio rerio) were available. Algae appear to be marginally the most sensitive level, although since the EC50 by growth rate was 8.93mg/l, it can reasonably be deduced that within margins of experimental error, all trophic levels show similar levels of toxicity. This supports the reasonable conclusion that the toxicity is non specific and acts through non-polar narcosis. This is backed up by the results from a reliable QSAR which predict LC/EC50 values all within a factor of ~3 or less of the measured values (predictions are more conservative.) The QSAR also predicts that the EC/LC50's across the difference species are all within <50% of each other and that the chronic values are a factor of <10 of the LC50 values. The results from a bioaccumulation study in fish also back up these conclusions. These observations should be taken into account in identifying an appropriate assessment factor for the PNEC derivation. Chronic data is avaiable for daphnia (21 day reproduction NOEC=1.51mg/l) and for algae (72 hr NOEC = 0.852mg/l). Toxicity to micro-organisms is lower than other aquatic species. The effect of test substance on the nitrifying activity of activated sewage sludge gave a 5-min EC50 of 150 mg/l. The No Observed Effect Concentration (NOEC) after 5-minutes exposure was 100 mg/l.
There is no measured data for the target substance VNB. However, QSAR data predicts consistently that ENB and VNB will have very similar toxicity, with, if anything VNB being marginally less toxic. The is supported by a structure and physicochemical property comparison which shows the two substances to be very similar. (See justification document attached to chapter 13). In conclusion, it appears both reasonable and conservative to use the results from ENB to read across to predict with confidence the aquatic toxicity properties of VNB.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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