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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 March 2011 to 25 March 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to EU & OECD test guidance in compliance with GLP and reported with a valid GLP certificate.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Details on test material:
- Name: Reactive Orange F08-0314
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- < -4.5
- Temp.:
- 20 °C
- pH:
- > 4.59 - < 4.66
- Details on results:
- Reactive Orange F08-0314 was not detected in the n-octanol phase.
Any other information on results incl. tables
Measured concentrations
Ratio of solvents (n-Octanol : Water) |
Measured concentration of Reactive Orange F08-0314 in n-octanol phase(μg/ml) |
Measured concentration of Reactive Orange F08-0314 in water phase(μg/ml) |
pH |
1:1 |
<0.13* <0.13 |
5212 5404 |
4.66 |
<0.13 <0.13 |
5432 5614 |
4.64 |
|
<0.13 <0.13 |
5570 5516 |
4.64 |
|
Mean (C) |
<0.13 |
5458 |
4.65 |
RSD% |
- |
3 |
- |
Meas. Test item (M) |
<3.2μg |
136mg |
- |
Total quantity of test item (Mo+Mw) in the two-phase system: |
136 mg |
||
Recovery: |
102% |
||
2:1 |
<0.13* <0.13 |
7687 7337 |
4.60 |
<0.13 <0.13 |
7952 8104 |
4.60 |
|
<0.13 <0.13 |
8062 8124 |
4.59 |
|
Mean (C) |
<0.13 |
7878 |
4.60 |
RSD% |
- |
4 |
- |
Meas. Test item (M) |
<4.3μg |
130mg |
- |
Total quantity of test item (Mo+Mw) in the two-phase system: |
130mg |
||
Recovery: |
97% |
||
1:2 |
<0.13* <0.13 |
4217 4138 |
4.62 |
<0.13 <0.13 |
4022 4492 |
4.63 |
|
<0.13 <0.13 |
4091 4424 |
4.63 |
|
Mean (C) |
<0.13 |
4233 |
4.63 |
RSD% |
- |
4 |
- |
Meas. Test item (M) |
<2.1μg |
142mg |
- |
Total quantity of test item (Mo+Mw) in the two-phase system: |
142mg |
||
Recovery: |
106% |
* Corresponds to the LOQ after the extraction
Calculated partition coefficient (Pow) and Log Pow
Ratio of solvents (n-Octanol : Water) |
Partition coefficient |
Log Partition coefficient |
Pow |
Log Pow |
|
1:1 |
<0.000024 |
<-4.6 |
2:1 |
<0.000016 |
<-4.8 |
1:2 |
<0.000030 |
<-4.5 |
Applicant's summary and conclusion
- Conclusions:
- In conclusion, the partition coefficient (Pow) of Reactive Orange F08-0314 in an n octanol - water two-phase system was determined to be less than 3.0 *.10-5 using shake flask method.
The log Pow is less than -4.5. The substance is not considered to have the propensity to bioaccumulate. - Executive summary:
This study has been performed in accordance with the study plan, Organisation for Economic Co-operation and Development (OECD), OECD Guidelines for Testing of Chemicals, Guideline No. 107, "Partition Coefficient (n-octanol/water): Shake Flask Method", adopted July 27, 1995 and Council Regulation (EC) No 440/2008 of 30 May 2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) Annex, Part A, Methods for the determination of physico-chemical properties, A.8 "Partition Coefficient", EEC Publication No. L142. and the Principles of Good Laboratory Practice (GLP). The study is reported with a valid GLP certificate.
The objective of the study was to determine the partition coefficient of the test item. The partition coefficient is the ratio of equilibrium concentrations of a dissolved test item in a two-phase system consisting of two largely immiscible solvents.
Summary of the results:
Partition coefficient (Pow) of Reactive Orange F08-0314 was determined using the shake-flask method.
Pow < 3.0 * 10-5
log Pow < -4.5
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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