Registration Dossier
Registration Dossier
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EC number: 418-280-1 | CAS number: 18600-59-4 CYASORB(R) UV-3638 LIGHT STABILISER
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Consumer Product Safety Commission-FHSA-Federal Hazards Substances Regulation, 16 CFR 1500
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,2-(1,4-phenylene)bis((4H-3,1-benzoxazine-4-one)
- EC Number:
- 418-280-1
- EC Name:
- 2,2-(1,4-phenylene)bis((4H-3,1-benzoxazine-4-one)
- Cas Number:
- 18600-59-4
- Molecular formula:
- C22H12N2O4
- IUPAC Name:
- 2-[4-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]-4H-3,1-benzoxazin-4-one
Constituent 1
Test animals
- Species:
- other: rabbit, albino New Zealand white
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: 0.9 % saline
- Duration of exposure:
- 24 h
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 6; Number of deaths: 1
Female: 2000 mg/kg bw; Number of animals: 4; Number of feaths: 0 - Gross pathology:
- Signs of toxicity related to dose levels:
One male animals died on day 4 of the study. Most animals were free of significant signs of systemic toxicity on the day of dosing. On the day after dosing, most animals exhibited decreased food consumption, which continued in some animals through Day 5, or sporadically throughout the study. - Other findings:
- Signs of toxicity (Local):
The test substance produced mild but transient dermal irritation. Most animals, at both the intact and abraded sites, exhibited very slight (barely perceptable) to slight erythema with little or no oedema. All irritation responses were resolved by Day 7.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
