Registration Dossier
Registration Dossier
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EC number: 253-506-0 | CAS number: 37439-34-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 2010
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Sodium 3,5,6-trichloropyridin-2-olate
- EC Number:
- 253-506-0
- EC Name:
- Sodium 3,5,6-trichloropyridin-2-olate
- Cas Number:
- 37439-34-2
- Molecular formula:
- C5HCl3NONa
- IUPAC Name:
- sodium 3,5,6-trichloropyridin-2-olate
- Details on test material:
- - Name of test material (as cited in study report): 2(1H)-pyridinone, 3,5,6-trichloro-, sodium salt
- Physical state: solid
- Analytical purity: 100%
- Lot/batch No.: 2010040701
- Storage condition of test material: Room temperature in the dark until 16th April 2010 then app. 4 C in the dark thereafter
- Other:
Constituent 1
Method
- Target gene:
- uvrB-
uvrA-
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Details on mammalian cell type (if applicable):
- - Type and identity of media: liver microsomal preparation (rat)
- Metabolic activation:
- with and without
- Metabolic activation system:
- rat liver homogenate metabolising system (10% liver S9 in standard co factors)
- Test concentrations with justification for top dose:
- Salmonella strains: 5, 15, 50, 150, 500, 1500, 5000 ug/plate
E. coli strain WP2 uvrA-: 15, 50, 150, 500, 1500, 5000 ug/plate
Controlsopen allclose all
- Positive controls:
- yes
- Positive control substance:
- N-ethyl-N-nitro-N-nitrosoguanidine
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- Positive controls:
- yes
- Positive control substance:
- 4-nitroquinoline-N-oxide
- Positive controls:
- yes
- Positive control substance:
- other: 2-aminoanthracene
- Positive controls:
- yes
- Positive control substance:
- benzo(a)pyrene
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
The test material was considered to be non-mutagenic under the conditions of test.
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