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EC number: 207-529-8 | CAS number: 479-27-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
- Version / remarks:
- Enrichment test of a chemical substance in the body of the fish and shellfish
- Deviations:
- not specified
- Principles of method if other than guideline:
- Method: semi-static
- GLP compliance:
- yes
- Remarks:
- audits and inspections carried out by department of the Foundation Chemicals Inspection Association chemical safety center Kyushu laboratory
- Specific details on test material used for the study:
- Test substance number K-602B
Purity: 100%
Identification via infrared spectroscopy, mass spectrometry and nuclear magnetic resonance spectroscopy
The test substance was confirmed to be stable under storage conditions and test conditions. - Radiolabelling:
- not specified
- Vehicle:
- yes
- Remarks:
- dimethyl sulfoxide
- Details on preparation of test solutions, spiked fish food or sediment:
- Preparative method:
- First concentration group: 0.8 g test substance dissolved in dimethyl sulfoxide was added dropwise to 8 L deionized water to prepare a stock solution of 100 mg/L.
- Second concentration group: 0.08 g test substance dissolved in dimethyl sulfoxide was added dropwise to 0.8 L deionized water to prepare a stock solution of 100 mg/L.
- Control: 80 mg Methyl sulfoxide was dissolved in deionized water. - Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- - Test fish: carp Cyprinus carpio
- Entry date: 1988-11-15
- Supplier: Sugishima fish farm (Yubinbangoa 66 Kumamoto Prefecture Yatsushiro Gunchikuichiban cho 123-2)
- Conditions for fish keeping: At reception, fish showing visible abnormal signs were removed and remaining ones kept for 32 days in running water at 25 +/- 2 °C..
- External disinfection: External disinfection was performed according to static condition for about 24 hours in a aqueous solution containing 50 mg/L Terramycin (from Pfizer) and 7 g/L sodium chloride.
- Weight: 22.1 g (average)
- Lenght: about 9.6 cm
- Lipid content: 3.8 %
- Feed: Pelleted feed for carp (Manufacturer: Nippon Formula Feed Mfg Co., Ltd.)
- Feeding amount and interval: Amount corresponding to about 2 % of the total body weight of test fish was fed twince a day by halves. On the day of fish sampling feed was not supplied. - Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Remarks:
- Ground water pumped at Kyushu laboratory site
- Total exposure / uptake duration:
- 6 wk
- Test temperature:
- 25 °C +/- 2 °C
- Dissolved oxygen:
- first concentration group: 6.2-7.6 mg/L;
second concentration group: 6.2-7.6 mg/L
control: 7.1-7.9 mg/L - Details on test conditions:
- - Test start: 1989-01-20
- Exposure start date: 1989-01-20
- Exposure end date: 1989-03-3
- Test end: 1989-03-9
- Test tank: Glass tank of 100 litre in volume
- Test water: 2 ml stock solution and 800 ml test water
- Number of fisch (at initiation of exposure): 15 fishes
- Number of fish in control group (at initiation of exposure): 7 fishes
- Duration of exposure: 6 weeks - Nominal and measured concentrations:
- first concentration: 0.1 mg/L
second concentration: 0.01 mg/L - Reference substance (positive control):
- not specified
- Lipid content:
- 3.8 %
- Time point:
- other: Λ v.
- Type:
- BCF
- Value:
- 3.6 dimensionless
- Basis:
- not specified
- Remarks on result:
- other: 3.6 ~ 6.1
- Remarks:
- Conc.in environment / dose:0.1 mg/L
- Type:
- BCF
- Value:
- < 3.7 dimensionless
- Basis:
- not specified
- Remarks on result:
- other: <3.7 ~ 6.5
- Remarks:
- Conc.in environment / dose:0.01 mg/L
- Reported statistics:
- Recovery rate
- Test water analysis: 89.6%, 87.7% average 88.6%
- Test fish analysis: 72.1% 75.2% average 73,6% - Validity criteria fulfilled:
- not specified
- Conclusions:
- The BCF to 1,8-naphthylenediamine was calculated for a concentration of 0.1 mg/L at 3.6 ~ 6.1 and for a concentration of 0.01 mg/L at <3.7 ~ 6.5.
- Executive summary:
The BCF to 1,8-naphthylenediamine was calculated for a concentration of 0.1 mg/L at 3.6 ~ 6.1 and for a concentration of 0.01 mg/L at <3.7 ~ 6.5.
Reference
Description of key information
The BCF to 1,8-naphthylenediamine was calculated to be 3.6 ~ 6.1 for a concentration of 0.1 mg/L and <3.7 ~ 6.5 for a concentration of 0.01 mg/L.
Key value for chemical safety assessment
- BCF (aquatic species):
- 6.5 dimensionless
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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