Registration Dossier
Registration Dossier
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EC number: 279-767-0 | CAS number: 81457-65-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles (TS purity not provided, 8-day observation period, no GLP).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- 8-day observation period
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Copper, [29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, [[3-(1-methylethoxy)propyl]amino]sulfonyl derivs.
- EC Number:
- 279-767-0
- EC Name:
- Copper, [29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, [[3-(1-methylethoxy)propyl]amino]sulfonyl derivs.
- Cas Number:
- 81457-65-0
- Molecular formula:
- Unspecified
- IUPAC Name:
- Copper, [29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, [[3-(1-methylethoxy)propyl]amino]sulfonyl derivs.
- Details on test material:
- No details provided
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CFE (RAC, SPF) strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Weight at study initiation: 126 - 143 g (mean: 135 - 136 g)
- Housing: groups of 5 animals in macrolon cages (size 3)
- Diet (ad libitum): Standard diet of Nafag; ad libitum
- Water (ad libitum): drinking water; ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 1 °C
- Humidity (%): 55 ± 5 %
- Photoperiod (hrs dark / hrs light): 14 hours light/day; 10 hours dark/day
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- 0.5% CMC in tap water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25 and 50% respectively for the low and high dose groups
MAXIMUM DOSE VOLUME APPLIED: 20 mL/kg bw - Doses:
- 5000 and 10000 mg/kg bw
- No. of animals per sex per dose:
- 5000 mg/kg bw: 5 male and 5 female animals
10000 mg/kg bw: 3 male and 2 female animals - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 8 days
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no mortality occurred up to this dose level
- Mortality:
- No mortality.
- Clinical signs:
- other: None observed. Black stained feces were observed in both dose groups.
- Gross pathology:
- No data.
Any other information on results incl. tables
Table 1: Body weights
Dose level (mg/kg bw) |
Mean body weights (g) |
|
Pre-test |
On day 8 of test |
|
5000 |
135 |
194 |
10000 |
136 |
195 |
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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