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EC number: 939-648-2 | CAS number: 75081-73-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- see read across justification
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: none reported
- Observations on body length and weight: NA
- Other biological observations: In the control and up to and including the highest test concentration 76 mg test item/L (32 mg solid content/L), all fish survived until the end of the test and no visible abnormalities were observed.
- Mortality of control: none
- Other adverse effects control: none
- Abnormal responses: none
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: No remarkable observations were made concerning the appearance of the test media.
- Effect concentrations exceeding solubility of substance in test medium: no
Based on the structural similarity, the results can be considered as relevant also for the registered substance. - Reported statistics and error estimates:
- The LC50 values at different observation times could not be calculated because up to the highest test concentration no mortality or any kind of symptoms were observed. The NOEC, LOEC, LC0 and LC100 were determined directly from the raw data.
- Sublethal observations / clinical signs:
In the control and up to and including the highest test concentration 32 mg solid content/L, all fish survived until the end of the test and no visible abnormalities were observed.The 96 hour NOEC and LC0of the test item to zebra fish were both determined to be 32 mg solid content/L. The 96 hour LC50of the test item was determined to be > 32 mg solid content/L.
Based on the structural similarity, the results can be considered as relevant also for the registered substance.
- Validity criteria fulfilled:
- yes
- Conclusions:
- In the present study the LC50 (96 h) for Danio rerio is derived at > 32 mg/L
- Executive summary:
In the Klimisch 1 GLP study from Kimmel (2013) the acute toxicity of Butanedioic acid, 2(or 3)-sulfo-, 4-[2-[(1-oxo(C12-C18(even numbered) and C18unsaturated)alkyl))amino]ethyl]esters, disodium salts to zebra fish (Danio rerio) was determined in a 96‑hour semi-static test with daily test medium renewal according to the EU Commission Directive 92/69/, Part C.1, the Commission Regulation (EC) No 440/2008, Part C.1 and the OECD Guideline for Testing of Chemicals No. 203 (1992). The following nominal concentrations of Butanedioic acid, 2(or 3)-sulfo-, 4-[2-[(1-oxo(C12-C18(even numbered) and C18unsaturated)alkyl))amino]ethyl]esters, disodium salts were tested: 0.76, 2.4, 7.6, 24 and 76 mg test item/L corresponding to 0.32, 1.0, 3.2, 10 and 32 mg solid content/L. Additionally, a control (test water without test item) was tested in parallel. The measured concentrations of the 32 mg solid content/L was within 94 and 101 % of the nominal concentrations. Consequently, the biological results are related to the nominal test item concentrations.
In the control and up to and including the highest test concentration 32 mg solid content/L, all fish survived until the end of the test and no visible abnormalities were observed. The 96 hour NOEC and LC0 of Butanedioic acid, 2(or 3)-sulfo-, 4-[2-[(1-oxo(C12-C18(even numbered) and C18unsaturated)alkyl))amino]ethyl]esters, disodium salts to zebra fish were both determined to be 32 mg solid content/L. The 96 hour LC50was determined to be > 32 mg solid content/L.
For C12-MEA (Butanedioic acid, 2(or 3)-sulfo-, 4 -[2 -[(1 -oxododecyl)amino]ethyl] ester, disodium salt) read across was made from the source chemical C12-C18/C18'-MEA (Butanedioic acid, 2(or 3)-sulfo-, 4-[2-[(1-oxo(C12 -C18(even numbered) and C18 unsaturated)alkyl))amino]ethyl]esters, disodium salts). Both substances have the same main C-Chain length of C12 (C12 -MEA 75 -90% C12,C12 -C18/C18'-MEA 45 -55%) . In C12 -MEA the C14 alkyl rest is represented with < 10% while in C12 -C18/C18'-MEA C14 comprises to 15-20%. This difference is considered small. It can be argued that C12-MEA is already part of C12 -C18/C18'-MEA. As mentioned before, the physical chemical parameters are similar. Within the N2 subgroup, the toxicity does not show a clear C-Chain dependency, i.e., the EC50/LC50 data for all members of this group are similar. Therefore, read across from C12 -C18/C18'-MEA (source) to C12 -MEA is considered as being justified.
Based on the data set and the supporting evidence for read across including the similarity of the C-Chain distribution, no further risk assessment factor is needed.The results of this study are considered relevant and reliable for the risk assessment.
Based on the structural similarity, the results can be considered as relevant also for the registered substance
Reference
Description of key information
96 h LC50: 32 mg/L
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 32 mg/L
Additional information
In the Klimisch 1 GLP study from Kimmel (2013) the acute toxicity of Butanedioic acid, 2(or 3)-sulfo-, 4-[2-[(1-oxo(C12-C18(even numbered) and C18unsaturated)alkyl))amino]ethyl]esters, disodium salts to zebra fish (Danio rerio) was determined in a 96‑hour semi-static test with daily test medium renewal according to the EU Commission Directive 92/69/, Part C.1, the Commission Regulation (EC) No 440/2008, Part C.1 and the OECD Guideline for Testing of Chemicals No. 203 (1992). The following nominal concentrations of Butanedioic acid, 2(or 3)-sulfo-, 4-[2-[(1-oxo(C12-C18(even numbered) and C18unsaturated)alkyl))amino]ethyl]esters, disodium salts were tested: 0.76, 2.4, 7.6, 24 and 76 mg test item/L corresponding to 0.32, 1.0, 3.2, 10 and 32 mg solid content/L. Additionally, a control (test water without test item) was tested in parallel. The measured concentrations of the 32 mg solid content/L was within 94 and 101 % of the nominal concentrations. Consequently, the biological results are related to the nominal test item concentrations.
In the control and up to and including the highest test concentration 32 mg solid content/L, all fish survived until the end of the test and no visible abnormalities were observed. The 96 hour NOEC and LC0 of Butanedioic acid, 2(or 3)-sulfo-, 4-[2-[(1-oxo(C12-C18(even numbered) and C18unsaturated)alkyl))amino]ethyl]esters, disodium salts to zebra fish were both determined to be 32 mg solid content/L. The 96 hour LC50was determined to be > 32 mg solid content/L.
For C12 -MEA (Butanedioic acid, 2(or 3)-sulfo-, 4 -[2 -[(1 -oxododecyl)amino]ethyl] ester, disodium salt)read across was made from the source chemical C12-C18/C18'-MEA (Butanedioic acid, 2(or 3)-sulfo-, 4-[2-[(1-oxo(C12 -C18(even numbered) and C18 unsaturated)alkyl))amino]ethyl]esters, disodium salts). Both substances have the same main C-Chain length of C12 (C12-MEA 75 -90% C12, C12-C18/C18'-MEA 45 -55%) . In C12-MEA the C14 alkyl rest is represented with < 10% while in C12 -C18/C18'-MEA C14 comprises to 15 -20%. This difference is considered small. It can be argued that C12 -MEA is already part of C12 -C18/C18'-MEA. As mentioned before, the physical chemical parameters are similar. Within the N2 subgroup, the toxicity does not show a clear C-Chain dependency, i.e., the EC50/LC50 data for all members of this group are similar. Therefore, read across from C12 -C18/C18'-MEA (source) to C12 -MEA is considered as being justified.
Based on the data set and the supporting evidence for read across including the similarity of the C-Chain distribution, no further risk assessment factor is needed.The results of this study are considered relevant and reliable for the risk assessment.
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