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EC number: 285-206-0 | CAS number: 85049-36-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Data investigating the aquatic toxicity of Fatty acids, C16-18 and
C18-unsatd., ethyl esters (CAS 85049-36-1) are not available.
In accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006,
read-across from structurally related substances was conducted to fulfil
the standard information requirements. In accordance with Article 13 (1)
of Regulation (EC) No 1907/2006, "information on intrinsic properties of
substances may be generated by means other than tests, provided that the
conditions set out in Annex XI are met.” In particular for aquatic
toxicity, information shall be generated whenever possible by means
other than vertebrate animal tests, which includes the use of
information from structurally related substances (grouping or
read-across). According to Annex XI, Item 1.5, of Regulation (EC) No
1907/2006 substances can be considered to be similar if their
physicochemical, toxicological and ecotoxicological properties are
likely to be similar or follow a regular pattern as a result of
structural similarity.
Fatty acids, C16-18 and C18-unsatd., ethyl esters (CAS 85049-36-1) and the read across substances Isopropyl oleate (CAS 112-11-8) and Fatty acids, C16-18 and C18-unsaturated isobutyl esters (CAS 84988-79-4) are monoesters of primary and secondary (isopropanol) alcohols C2-C4 and fatty acids. The fatty acid moiety comprises carbon chain lengths from C16-C18 and includes linear saturated and unsaturated fatty acid chains. The target substance and the source substances are characterised by a low water solubility, low vapour pressure and high log Koc. Thus, the substances are expected to have a similar environmental fate and ecotoxicity profile.
The available short-term and long-term studies indicate that the source substances are not acutely or chronically toxic to aquatic organisms up to the limit of water solubility of the source substances.
Data on the short-term toxicity to fish are covered by a read across to Isopropyl oleate (CAS 112-11-8). The acute toxicity of the substance to Cyprinus carpio was investigated in a standard OECD guideline study according to OECD 203. No mortality was observed after 96 h resulting in a LC50 > 100 mg/L (i.e. above the water solubility limit). The result is supported by a test performed by Loeb and Kelly (1963). In the static test Cyprinus carpio were exposed to the substance for 70 hours. A LC0 >= 118 mg/kg bdwt. based on mortality was observed.
The available short-term toxicity tests on aquatic invertebrates conducted with Fatty acids, C16-18 and C18-unsaturated isobutyl esters (CAS 84988-79-4) and Isopropyl oleate (CAS 112-11-8) reported no immobilization up to the limit of water solubility or the highest attainable concentration in test solution (EL(LC)50 > 100 mg/L). The assessment of the algal toxicity was based on a study available for Fatty acids, C16-18 and C18-unsaturated isobutyl esters (CAS 84988-79-4). The algae were exposed to filtered and unfiltered test solution respectively. An EC50 <100 mg/L was determined in the unfiltered test solution. Whereas an EL50>100 mg/L was reported for the filtered test solution. The observed effects in the unfiltered test solution were related to physical effects of the test substance.
Due to the low water solubility, long-term testing on aquatic invertebrates was considered to be necessary to assess the aquatic toxicity. The available study performed with Fatty acids, C16-18 and C18-unsaturated isobutyl esters (CAS 84988-79-4) resulted in a NOELR (21 d) ≥ 100 mg/L indicating no effects on reproduction up to the limit of water solubility. Long-term toxicity testing to fish was not considered to be necessary since there was no evidence from the available data that fish are more sensitive compared to aquatic invertebrates. No toxicity to fish was observed in the available acute tests. Thus, in order to avoid unnecessary vertebrate testing, no long-term testing with fish was proposed.
The available study on toxicity to aquatic microorganisms conducted with the source substance Isopropyl oleate (CAS 112-11-8) determined no detrimental effects.
Based on the result from a structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) it can be concluded that Fatty acids, C16-18 and C18-unsatd., ethyl esters (CAS 85049-36-1) is not acutely or chronically toxic to freshwater organisms up to the limit of the water solubility (WS < 0.05 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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