Registration Dossier
Registration Dossier
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EC number: 229-929-1 | CAS number: 6843-66-9
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (48 h) = 24 mg/L (mean measured, OECD 202) based on read across from CAS 947-42-2Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 24 mg/L
Additional information
No data concerning short term toxicity to aquatic invertebrates are available for the target substance Dimethoxydiphenylsilane (CAS 6843-66-9). Due to the rapid rate of hydrolysis of the substance (0.6 h at 20 -25°C and pH 7), it was considered appropriate to use measured data of its hydrolysis product Diphenylsilanediol (CAS 947-42-2) to determine the toxicity of the substance to aquatic invertebrates.
One study (2004) is available testing the short term toxicity of Diphenylsilanediol (CAS 947-42-2), which is the hydrolysis product of the target substance. The test was conducted according to OECD guidance 202. Daphnia magna was exposed for 48 h in a static regime to nominal test item concentrations of 0 (control), 13, 22, 36, 60 and 100 mg/L (mean measured: 0, 11, 19, 31, 52 and 87 mg/L). The test item concentrations were analytically monitored during the experiment via HPLC method. The recovery of the substance in the medium was > 80% of the nominal values. The test resulted in a 48-hour EC50 value of 24 mg/L (mean measured). The study is considered reliable and was selected as the key study.
Additional supporting information was withdrawn from a short term toxicity study (1995) of the related substance Cyclohexyldimethoxymethylsilane (CAS 17865-32-6). The test was conducted according to OECD guidance 202 and GLP standards. Daphnia magna as the test organism was exposed in a static system for 48 h to the nominal test item concentrations of 0 (control), 1, 1.8, 3.2, 5.6, 10, 18, 32, 56 and 100 mg/L. The study resulted in an EC50 (48 h) of 24 mg/L (nominal).
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