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EC number: 254-463-0 | CAS number: 39455-80-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 2006-06-20 to 2006-07-18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- adopted 1987-02-24
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- sodium trivanadium octaoxide
- IUPAC Name:
- sodium trivanadium octaoxide
- Reference substance name:
- Sodium trivanadium octaoxide
- EC Number:
- 234-709-3
- EC Name:
- Sodium trivanadium octaoxide
- IUPAC Name:
- 234-709-3
- Reference substance name:
- 12026-08-3
- Cas Number:
- 12026-08-3
- IUPAC Name:
- 12026-08-3
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): "SODIUMPOLYVANADATE (SPV)"
- Chemical name: Sodiumpolyvanadate
- Molecular formula: Na2V6O16
- Physical state: auburn powder
- Stability at conditions of storage: stable
- Storage condition of test material: at ambient temperature, in the dark
- Water solubility: hardly soluble
- Stability in aqueous solutions: stable
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS - CRL:CD(SD) BR SPF
- Source: Charles River Deutschland, D-97633 Sulzfeld
- Age at study initiation: approximately 8 weeks (males) and 12 weeks (females) at the time of the administration
- Weight at study initiation: males: 253 - 276 g; females: 232 - 257 g
- Housing: single caging in Makrolon cages type III (39 cm x 23 cm x 18 cm). Wire mesh lids. Aspen wood chips, type "ABEDD", (Fa. ABEDD Dominik Mayr KEG, A-8580 Köflach), autoclaved.
- Diet (ad libitum): Altromin 1324 forte (Producer: Altromin GmbH, D-32791 Lage) gamma irradiated with 25 kGy 60Co
- Water (ad libitum): tap water
- Acclimation period: at least 5 days
A health inspection was performed prior to the commencement of treatment to ensure, that the animals were in a good state of health. Special attention was paid to the skin to be treated, which was intact and free from any abnormality.
Nibbling wood bricks (10 cm x 2 cm x 2 cm) and nesting material, both from the same material and source as the bedding material, were offered to the animals once a week
ENVIRONMENTAL CONDITIONS
- Temperature: average of 22.2°C (continuous control and recording)
- Relative humidity: average of 53.0% (continuous control and recording)
- Air exchange: 12 per hour
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: a single dermal administration was performed by spreading the test substance on an area of at least 10% of the estimated body surface.
The test site was located on the dorsal thoracal region. An area of 6.5 cm x 8 cm (52 cm^2) was marked on a relaxed animal.
The hair of the dorsal trunk was clipped with an electrical hair clipper (Aesculap GH, 0.1 mm cutter head) one day before application of the test substance.
- Type of wrap if used: a cellulose patch (Pehazell, Hartmann AG) with the calculated amount of the test substance on the surface and soaked with deionised water to get optimal contact with the skin, was applied to the test site and held in place by fixing marginally with non irritating tape (Blenderm Wundpflaster, 3M).
Patch and tape were covered semi-occlusively by a dressing (Fixomull Stretch, Fa. Beiersdorf).
REMOVAL OF TEST SUBSTANCE
- Washing: residual test substance was wiped off using wet cellulose tissue, if necessary.
- Time after start of exposure: at the end of the exposure period the dressing, the tape and the patch were removed.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): the individual amounts of the test substance were calculated using the body weights determined on the day of the administration. - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males / 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 2 weeks
- Frequency of observations and weighing: observations were performed 0 - 0.5, > 0.5 - 1, > 1 -2, > 2 - 4 and > 4 - 6 hours after administration of the test substance and then at least once a day for a total of 2 weeks.
Body weights were determined before administration as well as 7 and 14 days after administration. Body weight gain was calculated for each week of the study, i.e. between 0 and 7 days and 7 and 14 days after administration.
- Necropsy of survivors performed: yes, all animals were killed by inhalation of 80% CO2 + 20% O2 14 days after administration and subjected to a necropsy including a gross pathological examination. - Statistics:
- not applicable
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals survived until the scheduled termination of the study.
- Clinical signs:
- other: General findings: all animals were normal during the entire observation period. Observations of skin condition: a light brown staining of the skin was observed in all animals from day 1 until a maximum of day 5 after administration. This stain is attribut
- Gross pathology:
- All animals were normal at terminal necropsy.
- Other findings:
- - Other observations: no noteworthy sex difference in the response to the test substance was derived from clinical observations or post-mortem findings.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 (male and female rats) > 2000 mg/kg bw
According to the EC-Commission directive 67/548/EEC and its subsequent amendments, the test substance is not classified.
According to the EC-Regulation 1272/2008 and subsequent regulations, the test item is not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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