Registration Dossier
Registration Dossier
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EC number: 700-288-4 | CAS number: 96441-14-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Year:
- 1 987
- Bibliographic source:
- Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 6307, - CHemIDplus Lite data base
Materials and methods
- Principles of method if other than guideline:
- Method not published.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]salicylamide monohydrochloride
- EC Number:
- 251-211-1
- EC Name:
- 5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]salicylamide monohydrochloride
- Cas Number:
- 32780-64-6
- IUPAC Name:
- 2-hydroxy-5-{1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl}benzamide hydrochloride
- Reference substance name:
- Benzamide, 2-hydroxy-5-(1-hydroxy-2-((1-methyl-3- phenylpropyl)amino)ethyl)-, monohydrochloride
- IUPAC Name:
- Benzamide, 2-hydroxy-5-(1-hydroxy-2-((1-methyl-3- phenylpropyl)amino)ethyl)-, monohydrochloride
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 114 mg/kg bw
Any other information on results incl. tables
Behavioral: convultion or effect on seizure threshold; altered sleep time (including change in righting reflex).
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- An acute oral toxicity study performed on the final product Labetalol HCl showed a LD50 value of 2114 mg/kg. The substance is not classified for this category.
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