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Diss Factsheets
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EC number: 209-578-0 | CAS number: 586-62-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In an acute oral toxicity study (similar to OECD Guideline No 401) performed in rats, the LD50 was 3740 mg/kg bw.
In an acute dermal toxicity study (similar to OECD Guideline No 402) performed in rabbits, the LD50 was higher than 4300 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 740 mg/kg bw
- Quality of whole database:
- Study performed similarly to OECD guideline 401 with deviations but considered as appropriate and reliable to complete this endpoint.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 4 300 mg/kg bw
- Quality of whole database:
- Study performed similarly to OECD Guideline No 402 with deviations but considered as appropriate and reliable to complete this endpoint.
Additional information
In an acute oral toxicity study (similar to OECD 401 Guideline), 4 groups of 10 rats were given a single oral dose of terpinolene monoconstituent at 3.0, 3.5, 4.0 and 5.0 mL/kg bw. Animals were then observed for mortality and clinical signs of toxicity. No clinical signs were observed. Deaths occured at 3.5 mL/kg bw and above.
The oral LD50 of terpinolene monoconstituent is 4.39 mL/kg bw in rats, corresponding to about 3740 mg/kg bw.
In an acute dermal toxicity study (similar to OECD 402 Guideline), four rabbits were administered a single dermal dose of terpinolene monoconstituent of 5 mL/kg bw. All animals were observed for mortality and clinical signs of toxicity. No mortality occurred at the tested dose level.
The acute dermal LD50 of terpinolene monoconstituent was considered to be higher than 5 mL/kg bw, corresponding to 4300 mg/kg bw.
Justification for selection of acute toxicity – oral endpoint
Only one study available for this endpoint
Justification for selection of acute toxicity – inhalation endpoint
Acute toxicity is already assessed by two different routes of exposure (oral and dermal routes), that showed very low toxicity, with high LD50 values.
Therefore in accordance with column 2 of REACH Annex VIII (section 8.5), the acute toxicity by inhalation does not need to be conducted.
Justification for selection of acute toxicity – dermal endpoint
Only study available for this endpoint
Justification for classification or non-classification
Oral and dermal LD50 are higher than 2000 mg/kg bw in rats and rabbits, respectively, therefore terpinolene monoconstituent is not classified for acute toxicity according to Directive 67/548/EEC and CLP Regulation (EC) No. 1272/2008.
However, based on its viscosity, terpinolene monoconstituent is classified for aspiration hazard Category 1 according to Regulation (EC) No. 1272/2008 (hydrocarbon with a kinematic viscosity of less than 20.5 mm2/s at 40°C) and as harmful "R65: may cause lung damage if swallowed" according to Directive 67/548/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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