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Diss Factsheets
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EC number: 203-875-9 | CAS number: 111-49-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- Acute inhalation toxicity test
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Perhydroazepine
- EC Number:
- 203-875-9
- EC Name:
- Perhydroazepine
- Cas Number:
- 111-49-9
- Molecular formula:
- C6H13N
- IUPAC Name:
- azepane
- Details on test material:
- - Name of test material (as cited in study report): Hexamethylenimine (HMI)
- Analytical purity: 98 %
- Lot/batch No.: Haskell No. 8588
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: ChR-CD
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- by gas chromatographie
- Duration of exposure:
- 4 h
- Concentrations:
- 0.52, 1.32, 1.95, 2.45, 2.77, 3.12 mg/L air
- No. of animals per sex per dose:
- 6-10 males per dose group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LCLo
- Effect level:
- 2.45 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: 1/6 animals died
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 2.77 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: 3/6 animals died
- Mortality:
- 0.52 mg/L: 0/10 animals died
1.32 mg/L: 0/6 animals died
1.95 mg/L: 0/6 animals died
2.45 mg/L: 1/6 animals died
2.77 mg/L: 3/6 animals died
3.12 mg/L: 6/6 animals died
Any other information on results incl. tables
Laboured breathing was observed in animals starting from 1.32 mg/l air. With increasing doses effects on the lungs, trachea (from laboured breathing to gasping, lung congestion (starting from 1.95 mg/l), nasal discharge) and eyes (corneal opacity) increased. These effects were verified by gross pathology in the ten rats examined.
Gross pathology showing subpleural white plaques, red focal spots, and congestion of the lung following 4-hour exposure to 2.77 mg/L.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the applied test conditions the test substance has an LC50 value of 2.77 mg/L air, the LCLo value is 2.45 mg/L air after a 4 h exposure.
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