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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1985
Report date:
1985

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Version / remarks:
1981
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
1-cyanoallyl acetate
EC Number:
239-743-2
EC Name:
1-cyanoallyl acetate
Cas Number:
15667-63-7
Molecular formula:
C6H7NO2
IUPAC Name:
1-cyanoprop-2-en-1-yl acetate

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Savo, Ivanovas Kisslegg
- Fasting period before study: on test day
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: > 5 days


ENVIRONMENTAL CONDITIONS
according to guideline


Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
according to guideline

REMOVAL OF TEST SUBSTANCE
- Washing: yes
- Time after start of exposure: 24 h


TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.00681-0.0681 mL/kg (males), 0.0147-0.0681 mL/kg (females)
- Constant concentration used: yes



Duration of exposure:
24 h
Doses:
6.95-69.5 mg/kg bw (males)
15.0-69.5 mg/kg bw (females)
No. of animals per sex per dose:
2-3
Control animals:
not required
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Statistics:
Probit Analysis

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
> 6.95 - < 15 mg/kg bw
Sex:
female
Dose descriptor:
LD50
Effect level:
32.2 mg/kg bw
Mortality:
Deaths occurred between 30 min and 2 h after application.
Clinical signs:
other: decrease of muscle tone, general loss of reflexes, streneous respiration, cyanosis, mydriasis. First symptoms 3-40 min post appl. persistant 2 to 3 h.
Gross pathology:
no substance related changes
Other findings:
formation of eschar at the exposed skin site; severe local reactions: nose bleedings, redness and crusts

Any other information on results incl. tables

The test substance was applied undiluted and caused severe local reactions (nose bleedings, redness and crusts) in addition to the systemic toxicity.

Applicant's summary and conclusion

Interpretation of results:
Category 1 based on GHS criteria
Remarks:
Migrated information