3-(triethoxysilyl)propiononitrile

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1956

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1956

Report date:

1956

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-(triethoxysilyl)propiononitrile

EC Number:

213-050-5

EC Name:

3-(triethoxysilyl)propiononitrile

Cas Number:

919-31-3

Molecular formula:

C9H19NO3Si

IUPAC Name:

3-(triethoxysilyl)propanenitrile

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS

- Age at study initiation: 3 to 5 months

- Weight at study initiation: mean 2.5 kg

Administration / exposure

Type of coverage:

not specified

Vehicle:

other: undiluted

Details on dermal exposure:

TEST SITE

- Area of exposure: the trunk

- Type of wrap if used: "Vinylite" sheeting was used to retain the dose in contact with the clipped skin of the trunk 


No other details on dermal exposure available.

Duration of exposure:

24 hours

Doses:

5.0 and 10.0 ml/kg bw

No. of animals per sex per dose:

6

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days

- Frequency of observations and weighing: No details available.

- Necropsy of survivors performed: yes

- Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: No details available.

Statistics:

Thompson's method of calculating the LD50 was used.

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

5 753 mg/kg bw

Based on:

test mat.

Mortality:

All animals died within one day at the 10.0 ml/kg bw dose level, one animal died on the first day at the 5.0 ml/kg bw dose level.

Clinical signs:

other: Skin erythema with slight necrosis in several cases resulted from these covered applications.

Gross pathology:

Dosage: 10.0 ml/kg bw: The lungs were slightly congested, the kidneys pale and pitted, and livers mottled.
Dosage: 5.0 ml/kg bw: None reported.

Other findings:

No other findings reported/available.

Any other information on results incl. tables

Table 1: Number of animals dead and time range within which mortality occurred

Dose (mg/kg bw)	Mortality (# dead/total)			Time range of deaths (day)
	Male	Female	Combined
5.0	1/3	-	1/3	1
10.0	3/3	-	3/3	1

 

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

In an acute dermal toxicity study available from an IUCLID summary, claimed to be conducted using a protocol comparable to the OECD Test Guideline 402 , but predating GLP, the LD50 was determined to be value of 5753 mg/kg bw/day in male New Zealand White rabbits.