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Diss Factsheets
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EC number: 939-154-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Literature data
Data source
Reference
- Reference Type:
- publication
- Title:
- Identification of Metal Allergens in the Local Lymph Node Assay.
- Author:
- Basketter David A., Lea Linda J, Cooper Karen J., Ryan Cindy A., Gerberick G. Frank, Dearman Rebecca J. and Kimber Ian.
- Year:
- 1 999
- Bibliographic source:
- American joumal of Contact Dermatitis, Vol. 10, No 4 (December), 1999: pp 207-212
Materials and methods
- Principles of method if other than guideline:
- Protocol described in Basketter et al., 1992. The local lymph node assay (LLNA) was used to determine the skin sensitization potential of 13 metal salts, 8 of which were considered to possess a significant ability to sensitize man. Treatment was performed once daily for 3 consecutive days. In order to assign to the metal a classification relating to skin sensitization the general principles outlined for such purposes by the European Union (EU) and the World Health Organization have been followed.
- GLP compliance:
- not specified
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Similar Substance 01
- IUPAC Name:
- Similar Substance 01
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Number: 4
- Source: Harland, Olac, Bicester, United Kingdom
- Age at study initiation: 7 to 12 weeks of age
Study design: in vivo (LLNA)
- Vehicle:
- dimethyl sulphoxide
- Concentration:
- 5.0, 10.0 and 25.0%
- No. of animals per dose:
- 4
- Details on study design:
- MAIN STUDY
TREATMENT PREPARATION AND ADMINISTRATION:
- Application: 25 µL of test material prepared with an equal volume of vehicle alone and applied to dersum of both ears.
- Administration: treatment was performed once daily for 3 consecutive days.
5 days after the initiation of exposure all mice were injected by the tail vein with 250 µL, of phosphate-buffer saline (PBS) containing 20 µCi of tritiated thymidine (2 Ci/mmol; Amersham International, Amersham, UK).
Mice were killed 5 hours later and the draining lymph nodes excised and pooled. A single-cell suspension of lymph node cells was prepared by mechanical disaggregation. The lymph node cell suspension was washed twice in an excess of PBS and then precipitated with 5% trichloroacetic acid (TCA) at 4°C for 18 hours. Pellets were resuspended in TCA and the incorporation of tritiated thymidine measured by β-scintillation counting. A substance was regarded as a skin sensitizer if, at any test concentration, the proliferation in treated lymph nodes was threefold or greater than that in the concurrent vehicle treated controls.
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- SI
- Remarks on result:
- other: 1.3, 2.0, 2.3 10 % zinc sulfate = 1.41
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- not sensitising
- Executive summary:
The local lymph node assay (LLNA) was used to determine the skin sensitization potential of 13 metal salts, 8 of which were considered to possess a significant ability to sensitize man. Treatment was performed once a day for 3 consecutive days. In order to assign to the metal a classification relating to skin sensitization the general principles outlined for such purposes by the European Union (EU) and the World Health Organization have been followed.
Result
Test substance resulted not sensitising.
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