Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 242-838-1 | CAS number: 19147-16-1
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1945
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP, short documentation, purity not specified, reliability of detection method unclear
- Objective of study:
- excretion
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
Adipic acid was orally administered to 4 different humans to investigate
the excretion of this compound. Urine was collected and the adipic acid concentration analyzed.- GLP compliance:
- no
- Radiolabelling:
- not specified
- Species:
- human
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- /
- Route of administration:
- other: no data
- Vehicle:
- not specified
- Details on exposure:
- /
- Duration and frequency of treatment / exposure:
- /
- Remarks:
- Doses / Concentrations:
/ - No. of animals per sex per dose / concentration:
- /
- Control animals:
- not specified
- Positive control reference chemical:
- /
- Details on study design:
- /
- Details on dosing and sampling:
- /
- Statistics:
- /
- Preliminary studies:
- /
- Details on absorption:
- /
- Details on distribution in tissues:
- /
- Details on excretion:
- /
- Test no.:
- #1
- Toxicokinetic parameters:
- other: One Person (70 kg) received 7 g adipic acid per day (100 mg/kg bw/day) over 10 days (70 g in total) given in several portions over the day. Urine was collected for these 10 days and two additional days after end of administration. 61% of the administere
- Metabolites identified:
- not specified
- Details on metabolites:
- /
- Bioaccessibility (or Bioavailability) testing results:
- /
- Conclusions:
- Interpretation of results (migrated information): no data
/
Reference
One Person (70 kg) received 7 g adipic acid per day (100 mg/kg bw/day) over 10 days (70 g in total) given in several portions over the day. Urine was collected for these 10 days and two additional days after end of administration. 61% of the administered dose was found in the urine. Three further persons received 23.4, 19.0, and 23.4 g adipic acid over 6, 5, and 9 days, respectively. 53% of the administered dose was found in the urine. No symptoms were reported during and after exposure
Description of key information
ryryr
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
