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Diss Factsheets
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EC number: 939-719-8 | CAS number: 5502-75-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 April 2012 to 26 July 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Statement of compliance in accordance with Directive 2004/9/EC (inspected on July 10, 2012 / signed on September 7, 2012)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Purity test date: 29-Feb-12 - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: 0, 24, 120 hours
- Buffers:
- pH 4: potassium hydrogen phthalate 0.005 mol dm-3
pH 7: Disodium hydrogen orthophosphate (anhydrous) 0.003 mol dm-3; Potassium dihydrogen orthophosphate 0.002 mol dm-3; Sodium chloride 0.002 mol dm-3
pH 9: Disodium tetraborate 0.001 mol dm-3; Sodium chloride 0.002 mol dm-3 - Estimation method (if used):
- Not applicable
- Details on test conditions:
- Sample solutions were prepared in stoppered glass flasks at a nominal concentration of 1 x 10-2 g/L in the three buffer solutions. A 1% co-solvent of tetrahydrofuran (THF) was used to aid solubility.
The concentration of each solution did not exceed the lesser of 0.01 mol/L or half the water solubility.
The test solutions were split into individual vessels for each data point.
The solutions were shielded from light whilst maintained at the test temperature.
A solution was prepared by weighing test item (0.1132 g) and dissolving in THF. This solution was diluted with pH 4, 7 and 9 buffers to give concentrations of 11.3 mg/L in each buffer.
Sample solutions at pH 4, 7 and 9 were maintained at 50.0 ± 0.5 °C for a period of 5 days. - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 10.6 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 10.6 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 9.9 mg/L
- Number of replicates:
- 2 replicates per pH
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- pH 4: Less than 10% hydrolysis after 5 days at 50ºC, equivalent to a half-life greater than 1 year at 25ºC.
pH 7: Less than 10% hydrolysis after 5 days at 50ºC, equivalent to a half-life greater than 1 year at 25ºC.
pH 9: Less than 10% hydrolysis after 5 days at 50ºC, equivalent to a half-life greater than 1 year at 25ºC. - Transformation products:
- no
- Details on hydrolysis and appearance of transformation product(s):
- Not applicable
- % Recovery:
- > 95.5 - < 98.8
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- > 98.3 - < 98.4
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- > 105.8 - < 107.6
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- Other kinetic parameters:
- None
- Details on results:
- Testing was originally performed at a working level of approximately 100 mg/L however at this concentration some issues were encountered with the test item not being fully soluble in the buffer solutions even with the use of a co-solvent. The excess test item was removed from the solution and the testing continued, however an apparent reduction in the test item concentration over time was observed with poor repeatability of results even from samples taken for the same time points. This was attributed to a combination of two factors. The first being that the excess test item was not entirely removed from the stock solutions, so when the stocks were split into separate test vessels there were variable quantities of excess added to each vessel causing inconsistent results. The second factor was possible loss of test item through volatilization from the test vessels.
To eliminate these problems the testing was repeated at a lower concentration to solve the solubility issue and using headspace vials for the test vessels in order to ensure a tight seal therefore reducing loss of test item through volatilization. - Results with reference substance:
- Not applicable
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test item was determined to be hydrolytically stable at pH 4, 7 and 9 (t½ > 1 year at 25 °C). No additional testing was performed at pH 1.2, 37.0 ± 0.5 °C.
- Executive summary:
Assessment of hydrolytic stability of the test substance was carried out using a procedure designed to be compatible with Method C7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004. The test substance was determined to be hydrolytically stable at pH 4, 7 and 9 (t½ > 1 year at 25 °C).
Reference
Description of key information
According to OECD 111 the test item was determined to be hydrolytically stable at pH 4, 7 and 9 (t½ > 1 year at 25 °C).
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
Assessment of hydrolytic stability of the registered substance was carried out using a procedure designed to be compatible with Method C7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004. The substance was determined to be hydrolytically stable at pH 4, 7 and 9 (t½ > 1 year at 25 °C).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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