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EC number: 201-164-8 | CAS number: 78-98-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian cell study: DNA damage and/or repair
- Remarks:
- Type of genotoxicity: DNA damage and/or repair
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No guideline study with acceptable restrictions.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- In vivo short-term assays for tumor initiation and promotion in the glandular stomach of Fischer rats
- Author:
- Furihata C. and T. Matsushima
- Year:
- 1 995
- Bibliographic source:
- Mutat. Res. 339, 15-35
- Reference Type:
- publication
- Title:
- Induction of ornithine decarboxylase and DNA synthesis in rat stomach mucosa by methylglyoxal
- Author:
- Furihata, C. et al.
- Year:
- 1 985
- Bibliographic source:
- Carcinogenesis 6 (1), 91-94
- Reference Type:
- publication
- Title:
- Mutagens and Carcinogens in Foods
- Author:
- Furihata, C. and Matsushima, T.
- Year:
- 1 986
- Bibliographic source:
- Ann. Rev. Nutr. 6, 67-94
- Reference Type:
- publication
- Title:
- Use of In Vivo / In Vitro Unscheduled DNA Synthesis for Identification of Organ Specific Carcinogens
- Author:
- Furihata, C. and Matsushima, T.
- Year:
- 1 987
- Bibliographic source:
- CRC Crit. Rev. Toxicol. 17 (3), 245-277
- Reference Type:
- publication
- Title:
- Prediction of Possible Carcinogens, Tumor-Promoters and Anti-Tumor Promoters in the Glandular Stomach
- Author:
- Furihata, C. and Matsushima, T.
- Year:
- 1 989
- Bibliographic source:
- Environ. Mol. Mut. 14, Suppl. 15, 63, Abstract Nr. 178
- Reference Type:
- publication
- Title:
- Prediction of Environmental Stomach Carcinogens and Promoters by In Vivo Short-Term Assay
- Author:
- Furihata, C. and Matsushima, T.
- Year:
- 1 987
- Bibliographic source:
- Environ. Mol. Mut. 9, Suppl. 8, 37, Abstract Nr. 92
Materials and methods
- Principles of method if other than guideline:
- Method: Determination of unscheduled DNA-synthesis (similar to OECD Guideline 486), ornithindecarboxylase activity, DNA-synthesis, DNA strand breaks and the number of S-phase cells in glandular stomach mucosa cells (Furihata, C. et al.: J. Natl. Cancer Inst. 72, 1327-1334 (1984))
- GLP compliance:
- not specified
- Type of assay:
- unscheduled DNA synthesis
Test material
- Reference substance name:
- Pyruvaldehyde
- EC Number:
- 201-164-8
- EC Name:
- Pyruvaldehyde
- Cas Number:
- 78-98-8
- Molecular formula:
- C3H4O2
- IUPAC Name:
- 2-oxopropanal
- Details on test material:
- Source: Nakarai Chemicals Ltd ., Kyoto, Japan)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Japan, Inc., Kanagawa, Japan
- Age at study initiation: 8 weeks
Administration / exposure
- Route of administration:
- other: stomach tube, oral gavage
- Vehicle:
- - Vehicle(s)/solvent(s) used: water for Methylglyoxal, DMSO for pos. control
- Amount of vehicle: 0.5 mL - Details on exposure:
- Animals were not fasted, but given a limited amount of diet (4 g of commercial pellet diet per rat of 200 g body weight) overnight to reduce their stomach contents. The following day they were treated either with 0.5 mL of test item in water or positive control item in DMSO.
- Duration of treatment / exposure:
- ODC activity (time dep.; 500 mg / kg bw): evaluated 4, 8, 16, 24, 48 and 72h post administration
ODC activity (dose dep.; 16h post admin.): evaluated at 0, 50, 200, 400 and 600 mg / kg bw
DNA synthesis (time dep.; 300 mg / kg bw): evaluated 4, 7, 16, 24, 48 and 72h post administration
DNA synthesis (dose dep.; 16h post admin.): evaluated at 0, 100, 200 and 300 mg / kg bw
DNA synthesis (dose dep.; 4h post admin.): evaluated at 0, 100, 300 and 500 mg / kg bw
S-Phase cells quantification (16h post admin. of 300 mg / kg bw) - Frequency of treatment:
- single dose
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50, 100, 200, 300, 400, 600 mg/kg bw
Basis:
nominal conc.
- No. of animals per sex per dose:
- five rats per sex per dose / time point (pooled)
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- - N-methyl-N'-nitro-N- nitrosoguanidine (MNNG, Aldrich Chemical Co., Milwaukee, WI, USA)
- Justification for choice of positive control: known glandular stomach carcinogen
- Route of administration: orally (gastric tube)
- Vehicle: DMSO
Examinations
- Tissues and cell types examined:
- Glandular stomach mucosa
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- positive
- Toxicity:
- not specified
- Vehicle controls validity:
- valid
- Negative controls validity:
- not applicable
- Positive controls validity:
- valid
Any other information on results incl. tables
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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