Registration Dossier
Registration Dossier
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EC number: 208-953-6 | CAS number: 548-62-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from secondary source
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Acute dermal toxicity for CAS no: 68955-35-1
- Author:
- U.S .National library of medicine
- Year:
- 2 017
- Bibliographic source:
- ChemID plus A TOXNET DATABASE.2017
- Reference Type:
- secondary source
- Title:
- IUCLID Dataset for CAS no: 68955-35-1
- Author:
- European Chemicals Bureau (ECB)
- Year:
- 2 000
- Bibliographic source:
- IUCLID Dataset, European Chemicals Bureau (ECB), 2000
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Acute dermal toxicity study of Naphtha (petroleum), catalytic reformed was performed in rabbits.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Naphtha (petroleum), catalytic reformed
- Cas Number:
- 68955-35-1
- Molecular formula:
- No data available
- IUPAC Name:
- Naphtha (petroleum), catalytic reformed
- Details on test material:
- - Name of test material (as cited in study report):Naphtha (petroleum), catalytic reformed
- Molecular formula :No data available
- Molecular weight :No data available
- Substance type:organic
- Physical state:No data available
- Purity:No data available
- Impurities (identity and concentrations):No data available
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Naphtha (petroleum), catalytic reformed
- Molecular formula :No data available
- Molecular weight :No data available
- Substance type:organic
- Physical state:No data available
- Purity:No data available
- Impurities (identity and concentrations):No data available
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 2000mg/kg
- No. of animals per sex per dose:
- Total:8
Male:4
Female:4 - Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No Mortality was observed
- Mortality:
- No Mortality was observed
- Clinical signs:
- other: Moderate to severe skin irritation was observed.
- Gross pathology:
- Necroscopy revealed thickened and crusted skin on test areas and red focii on the cortex of one rabbit kidney.
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be >2000mg/kg body weight. When rabbits were treated with Naphtha (petroleum), catalytic reformed (68955-35-1) by dermal application.
- Executive summary:
Acute dermal toxicity study was done in 4 male and 4 female New Zealand White rabbits using test material Naphtha (petroleum), catalytic reformed (68955-35-1).The skin of two male and two female animals were abraded before application.No mortality observed at dose 2000mg/kg. Clinical signs like moderate to severe skin irritation were observed in treated rabbits.Necroscopy revealed thickened and crusted skin on test areas and red focii on the cortex of one rabbit kidney.Hence LD50 was considered to be > 2000mg/kg body weight. When rabbits were treated with Naphtha (petroleum), catalytic reformed (68955-35-1) by dermal application.
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