Registration Dossier
Registration Dossier
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EC number: 939-633-0 | CAS number: 705279-64-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC = 100 mg/L (from ready biodegradation test, 67.3% biodegradation within 14 days in toxicity control)
Key value for chemical safety assessment
Additional information
No experimental data evaluating the toxicity of Glycerides, C8-21 and C8-21-unsaturated, mono- and di-, acetates (C10)(CAS No. 97593-30-1) to aquatic microorganisms are available. Therefore, read-across data from a structurally related category member, Glycerides, C8-21 and C8-21-unsaturated, mono- and di-, acetates (C12)(CAS No. 97593-30-1) is used in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Both substances are esters formed from the combination between acetylated fatty acids and glycerol as alcohol component. These two substances are structurally identical except for the length of their main fatty acid component (being either C10 or C12).The behaviour of these substances in the water phase is expected to be very similar based on their water solubility values (10.2-24.6 mg/L for the C10 and 3.5-21.9 mg/L for the C12 substances, respectively) and log Pow (> 4).
No standard studies evaluating the effect of Glycerides, C8-21 and C8-21-unsaturated, mono- and di-, acetates (C12)(CAS No. 97593-30-1) on respiration inhibition of aquatic microorganisms are available. Therefore, a ready biodegradability study is used to derive a NOEC for this endpoint. If a compound degrades well in a ready biodegradability test, or does not inhibit the degradation of a positive control at a certain concentration, this concentration can be used as a NOEC value. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2008).
A substance can be assumed to be not inhibitory of the activity of aquatic microorganisms if, in the toxicity control of a ready biodegradation test, more than 25% biodegradation occurs within a period of 14 days (OECD Guideline 301). For Glycerides, C8-21 and C8-21-unsaturated, mono- and di-, acetates (C12) a biodegradation screening test according to OECD 301F is available (Weyers, 2007). This test includes a toxicity control containing 100 mg/L of test material and reference substance (sodium benzoate). Within 14 days, 67.3% biodegradation took place in this toxicity control clearly indicating the lack of toxic potential of Glycerides, C8-21 and C8-21-unsaturated, mono- and di-, acetates (C12) to aquatic microorganisms, and therefore, the test item concentration of 100 mg/L can be used as a NOEC.
Based on the results obtained for the structurally similar analogue substance (in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5) inhibitory effects of Glycerides, C8-21 and C8-21-unsaturated, mono- and di-, acetates (C10) to aquatic microorganisms are not expected, and further testing is not deemed necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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