Registration Dossier
Registration Dossier
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EC number: 609-205-5 | CAS number: 361366-15-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according EU/OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- ethyl 1-{[2-(2,4,6-trimethylphenyl)acetyl]oxy}cyclopentane-1-carboxylate
- EC Number:
- 609-205-5
- Cas Number:
- 361366-15-6
- Molecular formula:
- C19H26O4
- IUPAC Name:
- ethyl 1-{[2-(2,4,6-trimethylphenyl)acetyl]oxy}cyclopentane-1-carboxylate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: demineralized water with 2 % Cremophor EL
- Doses:
- 2,000 mg/kg body weight (bw)
- No. of animals per sex per dose:
- 3 male and 3 female rats
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
Any other information on results incl. tables
Clinical Signs:
A dose of 2,000 mg/kg body weight was tolerated by male and female rats without mortalities.
At a dose of 2,000 mg/kg body weight in females no clinical signs were observed. In males diarrhea was observed 5 hours after administration.
Body Weights
There were no toxicological effects on body weights or on body weight development in males and females.
Gross Pathology Findings
No gross pathologic changes were observed in animals sacrificed at the end of the study period.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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