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Diss Factsheets
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EC number: 244-491-1 | CAS number: 21643-42-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 962
- Report date:
- 1962
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study was conducted according to an internal BASF method. Several groups of 5 mice per dose were treated intraperitoneally with preparations of the test substance in aqueous emulsion with traganth.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-Propenoic acid, C12-14-alkyl esters
- EC Number:
- 282-516-8
- EC Name:
- 2-Propenoic acid, C12-14-alkyl esters
- Cas Number:
- 84238-60-8
- Molecular formula:
- Unspecified
- IUPAC Name:
- 2-Propenoic acid, C12-14-alkyl esters
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Hannover
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Breeder: BASF AG
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: aqueous emulsion with traganth
- Doses:
- 3.2, 2.5, 2.0, 1.6, and 0.2 mL/kg bw (corresponding to 2784, 2175, 1740, 1392, and 174 mg/kg bw)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Group-wise documentation of clinical signs was performed over the 7-day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form. Upon completion of the study, all animals were sacrificed and submitted to gross-pathological examination.
- Statistics:
- On the basis of the observed lethality, the LD50 value was estimated using a graphical evaluation of the dose response curve on probability paper.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 910 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Exposure time: 168 hour(s)
- Mortality:
- - 174 mg/kg bw: All animals at this dose level survived until the end of the observation period.
- At the highest dose level, deaths occurred 48 h (4) and 72 h (1) after administration of the test compound. At 2175 mg/kg bw, 2 animals died within the first 24 hours after test start, then on day 4 and 5 one animal died, respectively (delayed mortality). - Clinical signs:
- - 174 mg/kg bw: On the day of test substance administration clinical signs observed were: slight apathy, ruffled fur and sunken flanks. At the 24 hours observation, these clinical signs had completely subsided.
- 1392 - 2787 mg/kg bw: At these dose levels, clinical signs on the day of test substance administration were also: ruffled fur and sunken flanks. Most animals showed a calm demeanor, and some apathy. After approx. 4 days the surviving animals were without clinical finding. - Gross pathology:
- Gross-pathological examination of the animals sacrificed at the end of the experiment revealed slight intraperitoneal agglutinations and encapsulated abscesses in the abdominal wall.
Any other information on results incl. tables
Mortality:
Dose Cumulative mortality after
[mg/kg bw] 1 h 24 h 48 h 7 d
-------------------------------------------------
2787 0/5 0/5 4/5 5/5
2175 0/5 2/5 2/5 4/5
1740 0/5 0/5 0/5 0/5
1392 0/5 0/5 0/5 1/5
174 0/5 0/5 0/5 0/5
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Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.