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Diss Factsheets
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EC number: 302-766-4 | CAS number: 94134-01-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- other: expert assessment
- Adequacy of study:
- key study
- Study period:
- 2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An assessment was performed based on available data on the substance and its constituents
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- An assessment was performed based on available data on the substance and its constituents
- GLP compliance:
- no
- Type:
- absorption
- Results:
- Following an exposure via the oral route the substance is expected to dissociate into its constituents. This is supported by experimental data on the substance. Dermal and inhalation routes are not considered relevant.
- Type:
- distribution
- Results:
- Its constituents are expected to be well-distributed in a mammalian body. This hypothesis is supported by experimental data on the substance.
- Type:
- metabolism
- Results:
- There is no data available on the registered substance and one of its constituents.
- Type:
- excretion
- Results:
- There is no data available on the registered substance and one of its constituents.
- Details on absorption:
- - Oral exposure: It is expected that following an exposure to the substance via the oral route, the registered substance will dissociate into its constituents nitrilotriacetic acid and 2-aminoethanol. Available data on these constituents indicate that they will be absorbed in the gastrointestinal tract. Following an exposure to the registered substance via the oral route, deaths were observed at 2,000 mg/kg bw, as well as adverse effects associated with systemic toxicity and a bodyweight loss. These findings indicate that absorption occurred following an oral exposure.
- Inhalation exposure: There is no data available on the substance following an inhalation exposure, which is not considered as a relevant route of exposure taking into account the uses of the substance.
- Dermal exposure: There is no data available on the substance following a dermal exposure, which is not considered as a relevant route of exposure taking into account the uses of the substance. - Details on distribution in tissues:
- Systemic effects observed following an oral exposure to the registered suggest a wide distribution in the body. Absorption of its constituents is expected to occur following an oral exposure. Both are hydrophilic compounds expected to be well-distributed in the body and unlikely to accumulate.
- Details on excretion:
- There is no data available on the elimination of the substance following an exposure via the oral, inhalation or dermal routes and the elimination of nitrilotriacetic acid. Respiration was identified as the main elimination route for 2-aminoethanol.
- Metabolites identified:
- not specified
- Details on metabolites:
- There is no data available on the metabolisation of the registered substance and Nitrilotriacetic acid. 2-aminoethanol is expected to be metabolised exhaled CO2, glycine, serine, choline, urea and uric acid.
- Conclusions:
- An assessment was performed based on available data on the substance and its constituents.
- Executive summary:
The absence of specific toxicokinetics data from animal testing means that it is not possible to make firm conclusions concerning the absorption, distribution, metabolisation and excretion of N,N’-bis(carboxymethylglycine) compound with 2-aminoethanol (1:3).
However, it is expected that the individual constituents of the substance will behave independently following oral and inhalation exposure and dermal penetration. Therefore the toxicokinetics behaviour of N,N’-bis(carboxymethylglycine) compound with 2-aminoethanol (1:3) is expected to be driven by the toxicokinetics behaviour of Nitrilotriacetic acid and 2-Aminoethanol.
It is expected that Nitrilotriacetic acid and 2-Aminoethanol will be absorbed and well distributed following an exposure via the oral route. The available experimental data on the registered substance supports the hypothesis that 2-aminoethanol and nitrilotriacetic acid are released in the body and well absorbed following an oral exposure. However, there is no data available allowing to confirm the distribution of the substance following absorption. Based on the uses of the substance no exposure via inhalation or the dermal route of N,N’-bis(carboxymethylglycine) compound with 2-aminoethanol (1:3) is expected.
No data is available on the metabolisation and elimination of Nitrilotriacetic acid and N,N’-bis(carboxymethylglycine) compound with 2-aminoethanol (1:3). 2-Aminoethanol was identified as being metabolised mainly into exhaled CO2.
It is not considered justified to perform animal studies on this substance to further investigate its toxicokinetics behaviour.
Reference
Description of key information
The absence of specific toxicokinetics data from animal testing means that it is not possible to make firm conclusions concerning the absorption, distribution, metabolisation and excretion of N,N’-bis(carboxymethylglycine) compound with 2-aminoethanol (1:3).
However, it is expected that the individual constituents of the substance will behave independently following oral and inhalation exposure and dermal penetration. Therefore the toxicokinetics behaviour of N,N’-bis(carboxymethylglycine) compound with 2-aminoethanol (1:3) is expected to be driven by the toxicokinetics behaviour of Nitrilotriacetic acid and 2-Aminoethanol.
It is expected that Nitrilotriacetic acid and 2-Aminoethanol will be absorbed and well distributed following an exposure via the oral route. The available experimental data on the registered substance supports the hypothesis that 2-aminoethanol and nitrilotriacetic acid are released in the body and well absorbed following an oral exposure. However, there is no data available allowing to confirm the distribution of the substance following absorption. Based on the uses of the substance no exposure via inhalation or the dermal route of N,N’-bis(carboxymethylglycine) compound with 2-aminoethanol (1:3) is expected.
No data is available on the metabolisation and elimination of Nitrilotriacetic acid and N,N’-bis(carboxymethylglycine) compound with 2-aminoethanol (1:3). 2-Aminoethanol was identified as being metabolised mainly into exhaled CO2.
It is not considered justified to perform animal studies on this substance to further investigate its toxicokinetics behaviour.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.