Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 302-766-4 | CAS number: 94134-01-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
N,N'-bis(carboxymethylglycine) compound with 2 -aminoethanol (1:3) is not deemed to be persistent in the marine environment based on the results of an OECD 301D and an OECD 306a ready biodegradability tests, during which ready biodegradability >100% and 88% at day 28. It is then concluded that the substance is not regarded as fulfilling the criteria for Persistence (P or vP).
The partition coefficient (log Kow) of the registered substance was determined to be below 0 indicating a lack of potential to bioaccumulate. Therefore, the substance does not meet the B or vB criteria.
In accordance with Annexes VII and VIII of REACH, no long-term toxicity study on the registered substance were performed for the purpose of this registration and no data on the long-term toxicity for marine/freshwater organisms was identified. Data on short-term toxicity of the registered substance to fish, aquatic invertebrates, and algae was provided. All L(E)C50 for short-term toxicity were above 1 mg/L and therefore above screening values for T properties described in Table R.11-6 of the Guidance on Information Requirements and Chemical Safety Assessment Chapter R.11: PBT/vPvB assessment (ECHA, 2017).
The toxicity of the substance was investigated in accordance with Annexes VII and VIII of REACH. In accordance with Regulation EC No 1272/2008, it was concluded that N,N’-bis(carboxymethylglycine) compound with 2-aminoethanol (1:3) does not meet the criteria for classification as carcinogenic category 1A or 1B, germ cell mutagenic category 1A or 1B, toxic for reproduction category 1A, 1B or 2, or STOT RE category 1 or 2. Therefore, the substance does not meet the T criteria.
N,N'-bis(carboxymethylglycine) compound with 2 -aminoethanol (1:3) does not meet the PBT and the vPvB criteria. It is not considered relevant to further investigate the PBT or vPvB properties of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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