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Diss Factsheets
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EC number: 206-557-8 | CAS number: 354-33-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
Description of key information
The solubility of HFC 125 in water at 25°C under atmospheric pressure has been estimated by the Henry's law constant experimentally derived by Arlt and co-workers.
Key value for chemical safety assessment
- Water solubility:
- 430 mg/L
- at the temperature of:
- 25 °C
Additional information
- Abraham et al. (2001) calculated an Ostwald coefficient (air-water at 25 °C) of -1.059 for HFC 125 starting from an experimentally derived HLC. The water solubility under atmospheric pressure calculated form the Ostwald coefficient result 430 mg/l and 295 mg/l at 25°C and 37°C, respectively.
- Miguel et al. (2000) indirectly determined the water solubility by measuring the change in the volume of HFC 125 in contact with a known volume of water at constant temperature and pressure (25°C and 101.325 kPa). The solubility under these experimental conditions resulted 3890 mg/l.
- DuPont (2004) determined the mutual solubility of water and HFC 125 under saturation conditions (i.e. the equilibrium among the 2 liquid phases and the gas phase. Under these conditions, HFC 125 solubilised in water is in equilibrium with a partial pressure equivalent to HFC 125 vapour pressure at 25 °C. Under this experimental conditions, a concentration of about 4600 mg/l was measured for HFC 125.
HFC-125 solubility in water at 25°C has been determined in 3 independent studies:
The Henry's law equation (Vp * Mw/ws = constant at constant temperature) demonstrates that the data from Abraham et al. is fairly consistent with the Dupont data:
(101325*120.02)/430 ≈ (1375800 * 120.02)/4600,
Whereas the Miguel et al. result seems to significantly overestimate the water solubility of HFC 125 under atmospheric pressure. For this reason, the study result from Abraham et al (2001) was selected as the most reliable.
Furthermore, the solubility of HFC 125 in physiological saline at 37°C was experimentally determined in 2 independent studies to be in the range 260 -350 mg/l (Ernstgard et al., 2010; Eger et al., 1994). Those results are in good agreement with the value of 295 mg/l calculated by Abraham et al., 2001 at 37°C, confirming then the validity of the Abraham's study.
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