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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 264-150-0 | CAS number: 63449-39-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 63.5 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Dose descriptor starting point:
- NOAEL
- Value:
- 900 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 1 562.5 mg/m³
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 450 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Additional information - workers
Acute Effects
LCCPs demonstrate a low order of acute toxicity. No mortalities were observed and the reported oral LD50values all exceeded 5,000 mg/kg bwt in the rat, mouse and dog. This conclusion is also supported by additional acute intraperitoneal (i.p.) studies in rats and mice that showed no mortality at 5,000 mg/kg bwt (i.p.) with several different LCCP test substances. The lack of acute toxicology data via inhalation or dermal exposure routes for LCCPs is not expected to be an important data gap as these routes of exposure are insignificant for LCCPs, which have very low vapour pressure and are absorbed very poorly through the skin.
DNELs for acute toxicity should be derived if an acute toxicity hazard, leading to classification and labelling (e.g. under EU CLP or DSD regulations), has been identified and there is a potential for high peak exposures (this is only usually relevant for inhalation exposures). As no acute hazard has been identified, then a DNEL for acute toxicity is unnecessary as the long-term DNEL will normally be sufficient to ensure that adverse effects do not occur. Consequently, no worker-DNELs for acute toxicity have been calculated.
Irritation/Sensitisation
LCCPs are not classified as skin or respiratory irritants or sensitisers. As such, there is no basis to establish DNELs based on localised effects.
Derivation of the DNELs
There are three sets of DNELs for LCCPs to cover the three main classes of LCCP:
- C18 -C20 Liquid LCCP
- C20 -C30 Liquid LCCP
- C20 -C30 Solid LCCP
The derivation of these DNELs is provided below:
C18-C20 LCCP (liquid)
Workers
Dermal - Long-Term Systemic Effects
Key Study: MCCP Repeat-Dose Study (Elcombe 2005b), Oral (gavage) exposure in rats
Dose Descriptor: NOAEL (systemic toxicity) = 23 mg/kg/day
Corrected Dermal NOAEL = Oral NOAEL x (ABSoral-rat/ABSdermal-human)
= 23 mg/kg/day x (0.5/0.01)[a]
Corrected Dermal NOAEL = 1150.0 mg/kg/day
Assessment Factors: Interspecies 4 (allometric scaling)
2.5 (remaining differences)
Intraspecies 5 (REACH guidance)
Exposure Duration 2 (subchronic to chronic)
Dose Response 1
Quality of Database 1
Total Assessment Factor: 100
DNELDermal - Long-Term Systemic= 1150.0 mg/kg/day ÷ 100
DNELDermal - Long-Term Systemic= 11.5 mg/kg/day
Inhalation - Long-Term Systemic Effects
Key Study: MCCP Repeat-Dose Study (Elcombe 2005b), Oral (gavage) exposure in rats
Dose Descriptor: NOAEL (systemic toxicity) = 23 mg/kg/day
Corrected Inhalation NOAEL = Oral NOAEL x (1/sRVrat)[b]x (ABSoral-rat/ ABSinhl-human)
= 23 mg/kg/day x (1 / 0.38m3kg-18hr-1) x (0.5/0.5)[c]
Corrected Inhalation NOAEL = 60.5 mg/m3 for 8hr
Corrected Inhalation NOAEL (workers) = 60.5 x (sRVhuman/ wRV)[d]
= 60.5 x (6.7 / 10)
Corrected Inhalation NOAEL (workers) = 40.5 mg/m3 for 8hr
Assessment Factors: Interspecies 2.5 (remaining differences)
Intraspecies 5 (REACH)
Exposure Duration 2 (subchronic to chronic)
Dose Response 1
Quality of Database 1
Total Assessment Factor: 25
DNELInhl - Long-Term Systemic= 40.5 mg/m3 for 8hr ÷ 25
DNELInhl - Long-Term Systemic= 1.62 mg/m3 for 8hr
C20-C30 LCCP (liquid)
Workers
Dermal - Long-Term Systemic Effects
Key Study: IRDC (1984b). IRDC Report No. 438-028/438-021 August 22, 1984 13-week oral gavage with combined excretion, tissue level and elimination study
Dose Descriptor: LOAEL (systemic toxicity) = 100 mg/kg/day (based on female LOAEL)
Corrected Dermal LOAEL = Oral LOAEL x (ABSoral-rat/ ABSdermal-human)
= 100 mg/kg/day x (0.5/0.01)[f]
Corrected Dermal LOAEL = 5,000.0 mg/kg/day
Assessment Factors: Interspecies 4 (allometric scaling)
2.5 (remaining differences)
Intraspecies 5 (REACH guidance)
Exposure Duration 2 (subchronic to chronic)
Dose Response 3 (using LOAEL)
Quality of Database 1
Total Assessment Factor: 250
DNELDermal - Long-Term Systemic= 5,000.0 mg/kg/day ÷ 250
DNELDermal - Long-Term Systemic= 20.0 mg/kg/day
Inhalation - Long-Term Systemic Effects
Key Study: IRDC (1984b). IRDC Report No. 438-028/438-021 August 22, 1984 13-week oral gavage with combined excretion, tissue level and elimination study
Dose Descriptor: LOAEL (systemic toxicity) = 100 mg/kg/day (based on female LOAEL)
Corrected Inhalation LOAEL = Oral LOAEL x (1/sRVrat)[g]x (ABSoral-rat/ ABSinhl-human)
= 100 mg/kg/day x (1 / 0.38m3kg-18hr-1) x (0.5/0.5)[h]
Corrected Inhalation LOAEL = 263.2 mg/m3 for 8hr
Corrected Inhalation LOAEL (workers) = 263.2 x (sRVhuman/ wRV)[i]
= 263.2 x (6.7 / 10)
Corrected Inhalation LOAEL (workers) = 176.3 mg/m3 for 8hr
Assessment Factors: Interspecies 2.5 (remaining differences)
Intraspecies 5 (REACH guidance)
Exposure Duration 2 (subchronic to chronic)
Dose Response 3 (LOAEL used)
Quality of Database 1
Total Assessment Factor: 75
DNELInhl - Long-Term Systemic= 176.3 mg/m3 for 8hr ÷ 75
DNELInhl - Long-Term Systemic= 2.35 mg/m3 for 8hr
C20-C30 LCCP (solid)
Workers
Dermal - Long-Term Systemic Effects
Key Study: LCCP Study IRDC (1984a). Report No. 438-027 / 438-024, Oral (gavage) exposure in rats
Dose Descriptor: NOAEL (systemic toxicity) = 900 mg/kg/day
Corrected Dermal NOAEL = Oral NOAEL x (ABSoral-rat/ ABSdermal-human)
= 900 mg/kg/day x (0.5/0.01)[k]
Corrected Dermal NOAEL = 45,000.0 mg/kg/day
Assessment Factors: Interspecies 4 (allometric scaling)
2.5 (remaining differences)
Intraspecies 5 (REACH guidance)
Exposure Duration 2 (subchronic to chronic)
Dose Response 1
Quality of Database 1
Total Assessment Factor: 100
DNELDermal - Long-Term Systemic= 45,000.0 mg/kg/day ÷ 100
DNELDermal - Long-Term Systemic= 450.0 mg/kg/day
Inhalation - Long-Term Systemic Effects
Key Study: LCCP Study IRDC (1984a). Report No. 438-027 / 438-024, Oral (gavage) exposure in rats
Dose Descriptor: NOAEL (systemic toxicity) = 900 mg/kg/day
Corrected Inhalation NOAEL = Oral NOAEL x (1/sRVrat)[l]x (ABSoral-rat/ ABSinhl-human)
= 900 mg/kg/day x (1 / 0.38m3kg-18hr-1) x (0.5/0.5)[m]
Corrected Inhalation NOAEL = 2368.4 mg/m3 for 8hr
Corrected Inhalation NOAEL (workers) = 2368.4 x (sRVhuman/ wRV)[n]
= 2368.4 x (6.7 / 10)
Corrected Inhalation NOAEL (workers) = 1586.8 mg/m3 for 8hr
Assessment Factors: Interspecies 2.5 (remaining differences)
Intraspecies 5 (REACH guidance)
Exposure Duration 2 (subchronic to chronic)
Dose Response 1
Quality of Database 1
Total Assessment Factor: 25
DNELInhl - Long-Term Systemic= 1586.8 mg/m3 for 8hr ÷ 25
DNELInhl - Long-Term Systemic= 63.5 mg/m3 for 8hr
[a]Based on MCCP oral and skin absorption efficiencies of 50% and 1.0%, respectively (MCCP Annex XV Report 2009).
[b]Standard respiratory volume (rat) = 0.38 m3/kg for 8 hours.
[c]Based on MCCP oral and inhalation absorption efficiencies of 50% (MCCP Annex XV Report 2009).
[d]Standard respiratory volume (human) = 6.7 m3for 8 hours; worker respiratory volume = 10 m3for 8 hours
[e]Based on MCCP oral and skin absorption efficiencies of 50% and 1.0%, respectively (MCCP Annex XV Report 2009).
[f]Based on MCCP oral and skin absorption efficiencies of 50% and 1.0%, respectively (MCCP Annex XV Report 2009).
[g]Standard respiratory volume (rat) = 0.38 m3/kg for 8 hours.
[h]Based on MCCP oral and inhalation absorption efficiencies of 50% (MCCP Annex XV Report 2009).
[i]Standard respiratory volume (human) = 6.7 m3for 8 hours; worker respiratory volume = 10 m3for 8 hours
[j]Based on MCCP oral and skin absorption efficiencies of 50% and 1.0%, respectively (MCCP Annex XV Report 2009).
[k]Based on MCCP oral and skin absorption efficiencies of 50% and 1.0%, respectively (MCCP Annex XV Report 2009).
[l]Standard respiratory volume (rat) = 0.38 m3/kg for 8 hours.
[m]Based on MCCP oral and inhalation absorption efficiencies of 50% (MCCP Annex XV Report 2009).
[n]Standard respiratory volume (human) = 6.7 m3for 8 hours; worker respiratory volume = 10 m3for 8 hours
[o]Based on MCCP oral and skin absorption efficiencies of 50% and 1.0%, respectively (MCCP Annex XV Report 2009).
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
Not applicable. Inhalation exposure not expected to the general population. LCCP have very low vapour pressure.
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 225 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Dose descriptor starting point:
- NOAEL
- Value:
- 900 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Dose descriptor starting point:
- NOAEL
- Value:
- 900 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Additional information - General Population
Acute Effects
LCCPs demonstrate a low order of acute toxicity. No mortalities were observed and the reported oral LD50values all exceeded 5,000 mg/kg bwt in the rat, mouse and dog. This conclusion is also supported by additional acute intraperitoneal (i.p.) studies in rats and mice that showed no mortality at 5,000 mg/kg bwt (i.p.) with several different LCCP test substances. The lack of acute toxicology data via inhalation or dermal exposure routes for LCCPs is not expected to be an important data gap as these routes of exposure are insignificant for LCCPs, which have very low vapour pressure and are absorbed very poorly through the skin.
DNELs for acute toxicity should be derived if an acute toxicity hazard, leading to classification and labelling (e.g. under EU CLP or DSD regulations), has been identified and there is a potential for high peak exposures (this is only usually relevant for inhalation exposures). As no acute hazard has been identified, then a DNEL for acute toxicity is unnecessary as the long-term DNEL will normally be sufficient to ensure that adverse effects do not occur. Consequently, no worker-DNELs for acute toxicity have been calculated.
Irritation/Sensitisation
LCCPs are not classified as skin or respiratory irritants or sensitisers. As such, there is no basis to establish DNELs based on localised effects.
Derivation of the DNELs
There are three sets of DNELs for LCCPs to cover the three main classes of LCCP:
- C18 -C20 Liquid LCCP
- C20 -C30 Liquid LCCP
- C20 -C30 Solid LCCP
The derivation of these DNELs is provided below:
C18-C20 LCCP (liquid)
General Population
Dermal - Long-Term Systemic Effects
Key Study: MCCP Repeat-Dose Study (Elcombe 2005b), Oral (gavage) exposure in rats
Dose Descriptor: NOAEL (systemic toxicity) = 23 mg/kg/day
Corrected Dermal NOAEL = Oral NOAEL x (ABSoral-rat/ ABSdermal-human)
= 23 mg/kg/day x (0.5/0.01)[e]
Corrected Dermal NOAEL = 1150.0 mg/kg/day
Assessment Factors: Interspecies 4 (allometric scaling)
2.5 (remaining differences)
Intraspecies 10 (REACH guidance)
Exposure Duration 2 (subchronic to chronic)
Dose Response 1
Quality of Database 1
Total Assessment Factor: 200
DNELDermal - Long-Term Systemic= 1150.0 mg/kg/day ÷ 200
DNELDermal - Long-Term Systemic= 5.75 mg/kg/day
Oral - Long-Term Systemic Effects
Key Study: MCCP Repeat-Dose Study (Elcombe 2005b), Oral (gavage) exposure in rats
Dose Descriptor: NOAEL (systemic toxicity) = 23 mg/kg/day
Assessment Factors: Interspecies 4 (allometric scaling)
2.5 (remaining differences)
Intraspecies 10 (REACH guidance)
Exposure Duration 2 (subchronic to chronic)
Dose Response 1
Quality of Database 1
Total Assessment Factor: 200
DNELOral - Long-Term Systemic= 23.0 mg/kg/day ÷ 200
DNELOral - Long-Term Systemic= 0.115 mg/kg/day
C20-C30 LCCP (liquid)
General Population
Dermal - Long-Term Systemic Effects
Key Study: IRDC (1984b). IRDC Report No. 438-028/438-021 August 22, 1984 13-week oral gavage with combined excretion, tissue level and elimination study
Dose Descriptor: LOAEL (systemic toxicity) = 100 mg/kg/day (based on female LOAEL)
Corrected Dermal LOAEL = Oral LOAEL x (ABSoral-rat/ ABSdermal-human)
= 100 mg/kg/day x (0.5/0.01)[j]
Corrected Dermal LOAEL = 5,000.0 mg/kg/day
Assessment Factors: Interspecies 4 (allometric scaling)
2.5 (remaining differences)
Intraspecies 10 (REACH guidance)
Exposure Duration 2 (subchronic to chronic)
Dose Response 3 (LOAEL used)
Quality of Database 1
Total Assessment Factor: 600
DNELDermal - Long-Term Systemic= 5,000.0 mg/kg/day ÷ 600
DNELDermal - Long-Term Systemic= 8.3 mg/kg/day
Oral - Long-Term Systemic Effects
Key Study: IRDC (1984b). IRDC Report No. 438-028/438-021 August 22, 1984 13-week oral gavage with combined excretion, tissue level and elimination study
Dose Descriptor: LOAEL (systemic toxicity) = 100 mg/kg/day (based on female LOAEL)
Assessment Factors: Interspecies 4 (allometric scaling)
2.5 (remaining differences)
Intraspecies 10 (REACH guidance)
Exposure Duration 2 (subchronic to chronic)
Dose Response 3 (LOAEL used)
Quality of Database 1
Total Assessment Factor: 600
DNELOral - Long-Term Systemic= 100.0 mg/kg/day ÷ 600
DNELOral - Long-Term Systemic= 0.167 mg/kg/day
C20-C30 LCCP (solid)
General Population
Dermal - Long-Term Systemic Effects
Key Study: LCCP Study IRDC (1984a). Report No. 438-027 / 438-024, Oral (gavage) exposure in rats
Dose Descriptor: NOAEL (systemic toxicity) = 900 mg/kg/day
Corrected Dermal NOAEL = Oral NOAEL x (ABSoral-rat/ ABSdermal-human)
= 900 mg/kg/day x (0.5/0.01)[o]
Corrected Dermal NOAEL = 45,000.0 mg/kg/day
Assessment Factors: Interspecies 4 (allometric scaling)
2.5 (remaining differences)
Intraspecies 10 (REACH guidance)
Exposure Duration 2 (subchronic to chronic)
Dose Response 1
Quality of Database 1
Total Assessment Factor: 200
DNELDermal - Long-Term Systemic= 45,000.0 mg/kg/day ÷ 200
DNELDermal - Long-Term Systemic= 225.0 mg/kg/day
Oral - Long-Term Systemic Effects
Key Study: LCCP Study IRDC (1984a). Report No. 438-027 / 438-024, Oral (gavage) exposure in rats
Dose Descriptor: NOAEL (systemic toxicity) = 900 mg/kg/day
Assessment Factors: Interspecies 4 (allometric scaling)
2.5 (remaining differences)
Intraspecies 10 (REACH guidance)
Exposure Duration 2 (subchronic to chronic)
Dose Response 1
Quality of Database 1
Total Assessment Factor: 200
DNELOral - Long-Term Systemic= 900.0 mg/kg/day ÷ 200
DNELOral - Long-Term Systemic= 4.5 mg/kg/day
[a]Based on MCCP oral and skin absorption efficiencies of 50% and 1.0%, respectively (MCCP Annex XV Report 2009).
[b]Standard respiratory volume (rat) = 0.38 m3/kg for 8 hours.
[c]Based on MCCP oral and inhalation absorption efficiencies of 50% (MCCP Annex XV Report 2009).
[d]Standard respiratory volume (human) = 6.7 m3for 8 hours; worker respiratory volume = 10 m3for 8 hours
[e]Based on MCCP oral and skin absorption efficiencies of 50% and 1.0%, respectively (MCCP Annex XV Report 2009).
[f]Based on MCCP oral and skin absorption efficiencies of 50% and 1.0%, respectively (MCCP Annex XV Report 2009).
[g]Standard respiratory volume (rat) = 0.38 m3/kg for 8 hours.
[h]Based on MCCP oral and inhalation absorption efficiencies of 50% (MCCP Annex XV Report 2009).
[i]Standard respiratory volume (human) = 6.7 m3for 8 hours; worker respiratory volume = 10 m3for 8 hours
[j]Based on MCCP oral and skin absorption efficiencies of 50% and 1.0%, respectively (MCCP Annex XV Report 2009).
[k]Based on MCCP oral and skin absorption efficiencies of 50% and 1.0%, respectively (MCCP Annex XV Report 2009).
[l]Standard respiratory volume (rat) = 0.38 m3/kg for 8 hours.
[m]Based on MCCP oral and inhalation absorption efficiencies of 50% (MCCP Annex XV Report 2009).
[n]Standard respiratory volume (human) = 6.7 m3for 8 hours; worker respiratory volume = 10 m3for 8 hours
[o]Based on MCCP oral and skin absorption efficiencies of 50% and 1.0%, respectively (MCCP Annex XV Report 2009).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.