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Diss Factsheets
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EC number: 202-626-1 | CAS number: 98-00-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 6 September 2006 (study initiiated), 6-15 August 2006 (experimental work completed)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non-guideline, human in-vitro study, no restrictions, fully adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
- Study type:
- other: investigation of in vitro metabolism in human nasal tissue
- Endpoint addressed:
- basic toxicokinetics
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The in-vitro metabolism of furfuryl alcohol was investigated in human nasal tissue.
- GLP compliance:
- no
Test material
- Reference substance name:
- Furfuryl alcohol
- EC Number:
- 202-626-1
- EC Name:
- Furfuryl alcohol
- Cas Number:
- 98-00-0
- Molecular formula:
- C5H6O2
- IUPAC Name:
- (furan-2-yl)methanol
- Details on test material:
- - Name of test material (as cited in study report): furfuryl alcohol
- Physical state: colourless liquid
- Analytical purity: 99.2%
- Source: Transfurans Chemicals BVBA, B-2440 Geel, Belgium
- Lot/batch No.: 060306PBP-A
- Storage condition of test material: in the dark at 4°C
Constituent 1
Method
- Type of population:
- other: tissue from patients undergoing medical procedures
- Subjects:
- Human nasal tissue consisted of nasal turbinates collected from 10 patients undergoing turbinectomy and septorhinoplasty procedures.
- Ethical approval:
- confirmed, but no further information available
- Route of exposure:
- other: in vitro exposure to human tissue
- Reason of exposure:
- other: In-vitro research study
- Details on exposure:
- Human nasal microsomes were incubated with 20mM furfuryl alcohol for 60 minutes.
Results and discussion
- Clinical signs:
- Not applicable
- Outcome of incidence:
- The biological oxidation products produced by liver microsomes and the chemical oxidation products of furfuryl alcohol had comparable retention times. The metabolite was not detected when furfuryl alcohol was incubated with human nasal tissues (see figure below). The glutathione S-transferase activity of the nasal tissue was consistent with published values for respiratory nasal tissue (124 nmol/min/mg protein).
Applicant's summary and conclusion
- Conclusions:
- In contrast to rat and mouse nasal tissue, the in vitro metabolism of furfuryl alcohol in human nasal tissue gave no detectable oxidation products using the methodology described.
- Executive summary:
A chemical oxidation product of furfuryl alcohol was generated by incubating furfuryl alcohol with m-chloroperoxybenzoic acid (mCPBA). The reaction products were trapped using semicarbazide and analysed by HPLC. The product formed by the biological oxidation of furfuryl alcohol in the rat liver microsomal incubations was found to have a comparable peak shape and retention time to that generated by the chemical oxidation of furfuryl alcohol. This product appears to be the same metabolite as identified in the previous research report (Mainwaring 2004). The samples were further analysed by LC/MS. However, the total ion current trace was weak and the response insufficient to give a mass spectrum.
This metabolite was not present in the incubation of furfuryl alcohol by human nasal tissue at levels above that of the negative controls.
In order to determine the viability of the tissue, a glutathione S-transferase assay was carried out using the cytosolic fraction of the tissue (there was insufficient microsomal protein left to determine any p450 reactions). The result of which demonstrated that the glutathione S-transferase activity is consistent with published data for respiratory nasal tissue at 124 nmol/min/mg protein (Banger et al 1993).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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