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Diss Factsheets
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EC number: 202-626-1 | CAS number: 98-00-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
Description of key information
Furfuryl alcohol is considered to show no significant neurotoxic potential.
Key value for chemical safety assessment
Additional information
In repeated dose studies (16-days and 90-days) no indication for neurotoxic effects was noted. No guideline neurotoxicity studies have been conducted and standard neurotoxicological endpoints (e.g. extended clinical observations, motor activity, functional observations, neuropathology) were not measured in the only published study investigating neurotoxicity (Savolainen and Pfaffli, 1983). At 50 and 100 ppm for 4 to 16 weeks rats were lighter than controls at the end of the experiment (without a clear dose-related response) and high dose rats were reported to have muscle hypotonia from 13th week onwards. Creatine kinase activity in cerebellar homogenate was increased at 50 and 100 ppm, succinate dehydrogenase activity was decreased at 100 ppm. Glial cell fractions showed decreased succinate dehydrogenase (week 16) and creatine kinase activity (weeks 9 and 16) at all dose levels and 2',3'-cyclic nucleotide 3'-phosphohydrolase and acid proteinase activity were increased at 100 ppm in week 16. Basic protein content of isolated myelin fractions was decreased compared to controls at 100 ppm at 16 weeks.
25 ppm was considered to be a NOAEL for nervous system effects.
Differences in the activity levels of specific enzymes in brain homogenates at dose levels also producing lower body weight are considered not to indicate specific neurotoxicity.Justification for classification or non-classification
No evidence of specific neurotoxic effects has been seen at dose levels that do not produce systemic toxicity and no classification is warranted with respect to this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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