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EC number: 438-600-3 | CAS number: 110675-26-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Since there is no data on acute toxicity for the substance (EC 438-600-3) available, a read-across to the structural analogon 4,6-bis(octylthiomethyl)-o-cresol has been conducted. It does not show acute oral and dermal toxicity with a LD 50s greater than 5000 mg/kg bw for the oral route of exposure and greater than 2000 mg/kg bw for the dermal route of exposure as shown in valid guideline studies performed pursuant to OECD Guidelines 401 (Acute Oral Toxicity) and 402 (Acute Dermal Toxicity), respectively. Experimental data on acute inhalation toxicity is waived.
Key value for chemical safety assessment
Additional information
No data on acute toxicity for the substance (EC 438-600-3) available. Read-across to 4,6-bis(octylthiomethyl)-o-cresol is applied.
The read-across substance differs in the length of the alkyl chain at the thio ether. Specifically, it is a C8 chain in comparison to a C12 chain in the target substance. Due to the shorter chain length, the molecule is smaller and predicted to be of slightly better solubility in water. Therefore, it is considered to be of better systemic availability which might result in a slightly higher toxicity compared to the target substance. As both C8 and C12 chains are metabolized via beta oxidation, both substances are predicted to have the same metabolites. Overall read-across is justified and it was accepted by the Competent Authority for ELINCS registration.
Oral Route of Exposure
In a limit test performed according to OECD Guideline 401 (Acute Oral Toxicity), groups of Tif: RAIf (SPF) rats (5 rats/sex/dose) were given a single oral dose (gavage) of the test substance at a single dose of 5000 mg/kg bw. The animals were observed subsequently for a period of 14 days. No mortality occurred during the14 day observation period. Dyspnoea, exophthalmoses, ruffled fur, and curved body position were seen, beginning as early as 1 hour post dosing and lasting up to 10 days. The animals fully recovered within 11 days. At necropsy, no gross lesions were observed. As no deaths occurred in the study, the LD 50 of the test article in rats is higher than 5000 mg/kg bw (Ciba Geigy Ltd., 861243).
Dermal Route of Exposure
In a limit test performed according to the OECD Test Guideline 402, a pilot sample was applied semi-occlusively for 24 hours to the shaved skin of 5 (7 - 8 weeks old) Tif: RAIf(SPF) albino rats /sex at a dose level of 2000 mg/kg bw. Animals were then observed for 14 days. No mortality was registered in the observation period. No local skin effects were observed at the application site. Treatment-related symptoms were dyspnoea, exophthalmoses, ruffled fur, and abnormal body position, which are common symptoms in acute tests. Additionally, sedation was found from three hours after the application up to day 1. All observed symptoms were reversible within 10 days after dosing. Necropsy revealed no gross abnormalities. As no deaths occurred in the study, the LD 50 of the test article in rats is higher than 2000 mg/kg bw (Ciba Geigy Ltd., 861246).
Inhalation Route of Exposure
No acute inhalation study is needed as acute oral and dermal studies are available (according to Annex VIII of REGULATION (EC) No 1907/2006).
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available experimental test data is reliable and suitable for the purpose of classification under Directive 67/548/EEC. Based on the data, classification for acute toxicity is not warranted under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC.
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for the purpose of classification under Regulation (EC) No.1272/2008. Based on the data, classification for acute toxicity is not warranted under Regulation (EC) No.1272/2008 as amended for the second time in Directive EC 286/2011..
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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