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EC number: 929-442-0 | CAS number: 1040871-35-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-09-08 to 1998-10-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- ; starting dose was not one of the four fixed levels given in the current guidelines
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- ; starting dose was not one of the four fixed levels given in the current guidelines
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Reaction mass of iso-tridecyl 3-mercaptopropionate and iso-dodecyl 3-mercaptopropionate
- IUPAC Name:
- Reaction mass of iso-tridecyl 3-mercaptopropionate and iso-dodecyl 3-mercaptopropionate
- Reference substance name:
- iso-Tridecyl 3-Mercaptopropionate
- Molecular formula:
- C16 H32 O2 S
- IUPAC Name:
- iso-Tridecyl 3-Mercaptopropionate
- Reference substance name:
- iso-Tridecyl 3-Mercaptopropionate
- IUPAC Name:
- iso-Tridecyl 3-Mercaptopropionate
- Reference substance name:
- Reaction mass of isotridecyl 3-mercaptopropionate and isododecyl 3-mercaptopropionate
- EC Number:
- 929-442-0
- Cas Number:
- 1040871-35-9
- IUPAC Name:
- Reaction mass of isotridecyl 3-mercaptopropionate and isododecyl 3-mercaptopropionate
- Details on test material:
- - Name of test material (as cited in study report): iso-tridecyl 3-mercaptopropionate
- Physical state: liquid
- Analytical purity: 99.7% w/w
- Purity test date: 1995-05-05
- Lot/batch No.: B98E2682
- Storage condition of test material: room temperature in the dark
comment: test substance used in this study
The study was performed with a test material identical to the submission substance (identical producer and identical way of synthesis). In the test report the test item is named iso-tridecyl-3-mercaptopropionate, which is used as the chemical name and as the trade name by the producer.
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Test animals
- Species:
- rat
- Strain:
- other: Sprague-Dawley Crl :CD (SD) IGS BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles RIver (UK) Ltd, Margate, Kent, UK
- Age at study initiation: 8-12 weeks
- Weight at study initiation: 203-227g (males), 204-217g (female)
- Fasting period before study: overnight fast before dosing
- Housing: in groups of up to three by sex in solid-floor polypropylene cages furnished with woodflakes
- Diet (e.g. ad libitum): free access to "Rat and Mouse Expanded Diet No. 1"; special diets services limited; Witham; Essex; UK
- Water (e.g. ad libitum): free access
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-25°C
- Humidity (%): 47-64%
- Air changes (per hr): approximately fifteen
- Photoperiod (hrs dark / hrs light): 12h / 12h
IN-LIFE DATES: From: 2008-09-08 To: 2008-10-12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20, 50 and 200mg/mL
- Amount of vehicle (if gavage): 10mL/kg
- Justification for choice of vehicle: test substance did not dissolve in distilled water or other aqueous vehicles
MAXIMUM DOSE VOLUME APPLIED: 10mL/kg
DOSAGE PREPARATION (if unusual): formulations were dosed within 42 minutes of preperation
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: 200mg/kg was suggested - Doses:
- 200, 500 and 2000mg/kg bw
- No. of animals per sex per dose:
- 3 males and three females for dose group 200 and 500mg/kg bw;
3 females for dose group 2000mg/kg bw - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 0.5, 1, 2 and 4h after dosing and subsequently once daily (signs of toxicity); prior to dosing and 7 and 14 days after treatment (weighing)
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight and necropsy - Statistics:
- not applicable
Results and discussion
- Preliminary study:
- none
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 500 - < 2 000 mg/kg bw
- Mortality:
- No mortalities were noted at 200 or 500 mg/kg bw. Two animals treated with 2000 mg/kg were found dead during the day of dosing and the remaining animal treated with 2000 mg/kg was found dead one day after dosing.
- Clinical signs:
- other: Common signs of systemic toxicity noted, prior to death, in animals treated with 2000mg/kg were hunched posture, lethargy, decreased respiratory rate, laboured respiration, prostation, tonic convulsions, increased salivation with incidents of pallor of th
- Gross pathology:
- Abnormalities noted at necropsy of animals that died during the study were haemorrhagic lungs, dark liver and dark kidneys. No abnormalities were noted at necropsy of animals that were killed at the end of the study.
- Other findings:
- none
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral LD50 of the test material was determined to be greater than 500mg/kg but less than 2000mg/kg bw.
- Executive summary:
A study was performed to assess the acute oral toxicity of the test material following a single oral administration to the SpragueDawley CD strain rate. The method used was according to the "Acute toxic Class Method”.
Using all available information, 200mg/kg bodyweight was selected as the starting dose. A group of three fasted females was treated with the starting dose of 200mg/kg. This was followed by a group of three fasted males at the same dose level. Based on the results from this dose level a further group of fasted females was treated at a dose level of 2000mg/kg bodyweight and a further group of fasted males and females was treated at a dose leve of 500mg/kg bw. Dosing was performed sequentially.The test material was administered orally as a solution in arachis oil. Clinical observations were performed 0.5 1, 2 and 4 hours after dosing and then once daily for up to fourteen days. Bodyweights were recorded on Day 0 (day of dosing) and on Days 7 and 14, or at death. At the end of the observation period the surviving animals were killed by cervical dislocation. All animals were subjected to gross necropsy.
Two females treated with 2000mg/kg were found dead during the day of dosing and the remaining female treated with 2000mg/kg was found dead one day after dosing. Clinical signs of toxicity noted, prior to death, in animals treated with 2000mg/kg were hunched posture, lethargy, decreased respiratory rate, laboured respiration, prostration, ataxia, increased salivation, tonic convulsions and pallor of the extremities. Clinical signs of toxicity noted in animals treated with 500mg/kg were hunched posture, up to one day after dosing. No clinical signs of toxicity were noted in animals treated with 200mg/kg. The surviving animals showed expected gains in bodyweight over the study period.
Abnormalities noted at necropsy of animals that died during the study were haemorrhagic lungs, dark liver and dark kidneys. No abnormalities were noted at necropsy of animals that were killed at the end of the study.Mortalities were noted at a dose level of 2000mg/kg bodyweight. No mortalities were noted in animals treated with 200 or 500mg/kg bw.
The acute oral LD50 of the test material was determined to be greater than 500mg/kg but less than 2000mg/kg bw.
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