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EC number: 614-283-9 | CAS number: 68127-59-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1986-10 to 1987-02-24
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- Limit concentration of 5 mg/L or recommended concentration of 2 mg/L not reached, and no rationale given. Mass median aerodynamic diameter of aerosols >4 micrometer (5.3 and 7.3 micrometer, at lower and higher concentration, respectively).
- GLP compliance:
- yes
- Remarks:
- Summary report derived from a study which fulfills the requirements of GLP; not further documented
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- reaction mass of (1R,3R)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylic acid and (1S,3S)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylic acid
- EC Number:
- 614-283-9
- Cas Number:
- 68127-59-3
- Molecular formula:
- C9H10ClF3O2
- IUPAC Name:
- reaction mass of (1R,3R)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylic acid and (1S,3S)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylic acid
- Details on test material:
- - Physical state: finely divided powder
- Colour: white
- Expiration date of the lot/batch: not reported
- Storage condition of test material: not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alpk:AP
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not reported
- Age at study initiation, weight at study initiation: not reported
- Fasting period before study: not reported
- Housing, diet, water: not reported
- Acclimation period: not reported
ENVIRONMENTAL CONDITIONS
- not reported
IN-LIFE DATES: From: To: not reported
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus, chamber volume, method of holding animals in test chamber: not reported
- Source and rate of air, conditioning air: not reported
- System of generating particulates/aerosols: Wright's dust feed
- Method of particle size determination: Marple cascade impactor
- Treatment of exhaust air: not reported
- Temperature, humidity, pressure in air chamber: not reported
TEST ATMOSPHERE
- Brief description of analytical method used: 25mm open-faced filters, gravimetric determination likely (since no reference to analytical method is given)
- Samples taken from breathing zone: no data
VEHICLE
- none
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution:
at 0.09 mg/L: 84% inhalable (<= 15 micrometer aerodynamic equivalent diameter AED), 23% respirable (<= 2.5 micrometer AED);
at 1.1 mg/L: 79% inhalable (<= 15 micrometer AED), 12% respirable (<= 2.5 micrometer AED);
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): MMAD at 0.09 mg/L: 5.3 micrometer, at 1.0 mg/L: 7.3 micrometer; GSD not reported
- Rationale for the selection of the starting concentration: none given - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- no analytical method reported; probably gravimetric
- Duration of exposure:
- 4 h
- Concentrations:
- nominal: 0.1 and 1.0 mg/L
analytical: 0.09 +/- 0.01 mg/L and 1.1 +/- 0.1 mg/L - No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not reported
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights (lungs and liver) - Statistics:
- None (no mortalities observed)
Results and discussion
- Preliminary study:
- None reported
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- >= 1.1 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 1.1 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: No mortalities observed
- Mortality:
- None observed
- Clinical signs:
- other: Animals exposed to the high concentration had test material around their snouts. Stains around the snout, chromodacryorrhea and wet fur during exposure, as well as hunched posture and piloerection immediately following exposure were observed both in the t
- Body weight:
- No average or individual data are presented in the report. No toxicologically significant effects on body weight or weight gain were observed.
- Gross pathology:
- No significant macropathological changes were observed in the treated animals.
- Other findings:
- - Organ weights: At 1.1 mg/L, the liver/body weight ratio was statistically significantly lowered in males, although the reduction was very small (7%, with no associated clinical or post-mortem findings). All other organ weights (absolute and relative) were normal. Neither average nor individual values are tabulated in the report.
Applicant's summary and conclusion
- Interpretation of results:
- other: not conclusive
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The acute inhalation LC50 of the test substance was estimated to be greater than 1.1 mg/L to male and female rats. Confidence limits could not be calculated. The study report is relevant, but not adequate and reliable for classification and labeling.
- Executive summary:
The acute inhalation toxicity of the test material (a powder) was assessed according to a method similar to OECD 403 in groups of five male and five female rats, at analytical aerosol concentrations of 0.1 mg/L and 1.1 mg/L. The test substance aerosols were generated using a Wright’s dust feed, quantified by deposition on 25 mm open-faced filters, and their particle size distribution was assessed with a Marple cascade impactor. The mass median aerodynamic diameters obtained were 5.3 micrometer at 0.1 mg/L, and 7.3 micrometer at 1.1 mg/L. No attempt to reach the aerosol concentration recommended in OECD 403 (2 mg/L) or the limit test condition (5 mg/L) was reported. Mortalities, signs of toxicity, body and organ (lung and liver) weight developments were recorded during 14 days; survivors were examined by necropsy for macroscopic abnormalities.
Mortalities were not observed, so that a statistical calculation of the LC50 could not be performed. The clinical symptoms, stains around the nose, piloerection, and hunched posture, though persisting up to day 15, were considered a mild, non-specific response to exposure. Body and organ weights developed normally, except for a slight but statistically significant decrease (7%) of the relative liver weight in the males of the higher concentration group. No macroscopical abnormalities were detected.
From the absence of mortalities (LC0>1.1 mg/L), the acute inhaltation LC50 > 1.1 mg/L was estimated.
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