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Diss Factsheets

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information
In one experiment, the test substance inhibited growth of strain TA1537 without activation, reducing the colony count by more than 50% at 5000 micrograms/plate.
Link to relevant study records
Reference
Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
other: Annex V (Ames)
GLP compliance:
yes
Type of assay:
bacterial reverse mutation assay
Species / strain / cell type:
bacteria, other: Salmonella typhimurium TA98, TA100, TA1535, TA1537 E.Coli WP2 uvrA
Metabolic activation system:
Aroclor-induced Rat liver S9
Test concentrations with justification for top dose:
Concentration range in the main test (with metabolic activation): 312.5 ... 5000 µg/plate
Concentration range in the main test (without metabolic activation): 312.5 ... 5000 µg/plate
Vehicle / solvent:
Solvent: Acetone
Species / strain:
other: as specified above
Metabolic activation:
with
Cytotoxicity / choice of top concentrations:
cytotoxicity
Remarks:
(> 5000 µg/plate)
Species / strain:
other: as specified above
Metabolic activation:
without
Cytotoxicity / choice of top concentrations:
cytotoxicity
Remarks:
(> 5000 µg/plate)
Remarks on result:
other: other: main test
Remarks:
Migrated from field 'Test system'.

None.

Conclusions:
Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation

None.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

Additional information from genetic toxicity in vitro:

In one experiment, the test substance inhibited growth of strain TA1537 without activation, reducing the colony count by more than 50% at 5000 micrograms/plate.

Justification for classification or non-classification

non-classification