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Diss Factsheets
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EC number: 941-814-4 | CAS number: 157367-45-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 1991 to January 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented OECD guideline study
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- not relevant
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 308 AQN
- IUPAC Name:
- 308 AQN
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- At the start of the study the animals weighed 2.44 - 2.59 kg and were twelve to sixteen weeks old. After a minimum acclimatiation period of five days each animal was given a number unique within the study which was written with black indelible marker-pen on the inner surface of the ear and on the cage label.
The animals were individally housed in suspended metal cages. Free access to mains drinking water and food (Spiller Rabbit Diet, Degety Agriculture Ltd., Almondsbury, Bristol) was allowed throughout the study.
The animal room was maintained at a temperatire of 17 - 21 °C and relative humidity of 35 - 55 %. The rate of air exchange was approximately 15 charges per hour and the lighting was controlled by a time switch to give continuous 12 hours light and 12 hours darkness.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- A quantity of 0.5 g of the test material, moistered with 0.6 ml of distilled water, was introduced under a 2.5 cm * 2.5 cm gauze patch and placed in position on the shorn skin.
- Duration of treatment / exposure:
- 4 hours.
- Observation period:
- 1 hour following the removal of the patches, and 24, 48 and 72 hours later, the test sites were examined.
- Number of animals:
- 3 rabbits
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm * 2.5 cm
- Type of wrap if used: gauze patch
REMOVAL OF TEST SUBSTANCE
- Washing (if done): gentle swabbing with distilled water
- Time after start of exposure: after 4 hours
SCORING SYSTEM: Primary irritation index
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: After 72 hour observation
- Score:
- 2.3
- Max. score:
- 2
- Irritant / corrosive response data:
- Very slight to well-defined erythema was noted at all treated skin sites at the 48-hour observation. Very slight erythema was noted at two treated skin sites at the 72-hour observation.
Very slight oedeme was noted at one treated skin site one hour after patch removal. Slight oedema was noted at two treated skin sites at the 24-hour observation with very slight to slight oedema at the 48 and 72-hour observations. - Other effects:
- Desquamation was confined to two treated skin sites seven days after treatment.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The test material, No. 308 AQN, produced a primary irritation index of 2.3 and was classified as a moderate irritant to rabbit skin according to the Draize classification scheme. No corrosive effects were noted.
The test material produced possitive criteria in 1/3 rabbits according to the ECC labelling regulations and was classified as non-irritant to rabbit skin. No symbol and risk phrase are therefore required. - Executive summary:
The test material, No. 308 AQN, produced a primary irritation index of 2.3 and was classified as a moderate irritant to rabbit skin according to the Draize classification scheme. No corrosive effects were noted.
The test material produced possitive criteria in 1/3 rabbits according to the ECC labelling regulations and was classified as non-irritant to rabbit skin. No symbol and risk phrase are therefore required.
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